Naphthyl piperazines with dual activity as 5-HT1D antagonists and 5-HT reuptake inhibitors - Bueno, Ana B.; Gilmore, Jeremy; Boot, John; Broadmore, Richard; Cooper, Jane; Findlay, Jeremy; Hayhurst, Lorna; Marcos, Alicia; Montero, Carlos; Mitchell, Stephen; Timms, Graham; Tomlinson, Rosemarie; et al. (Bioorganic & medicinal chemistry letters, 2007)
Keywords: Animals; Antidepressive Agents - chemical synthesis; Antidepressive Agents - pharmacology; Biological and medical sciences; Dose-Response Relationship, Drug; Guinea Pigs; Kinetics; Medical sciences; Models, Chemical; Naphthalenes - chemistry; Neuropharmacology; Neurotransmitters. Neurotransmission. Receptors; Pharmacology. Drug treatments; Piperazines - chemical synthesis; Piperazines - pharmacology; Receptor, Serotonin, 5-HT1D - drug effects; Receptor, Serotonin, 5-HT1D - metabolism; Serotonin Antagonists - chemical synthesis; Serotonin Antagonists - pharmacology; Serotonin Uptake Inhibitors - chemical synthesis; Serotonin Uptake Inhibitors - pharmacology; Serotoninergic system; Stereoisomerism; Structure-Activity Relationship; Serotonin; Rodentia; Oral administration; Selectivity; Reuptake inhibitor; In vitro; Naphthalene derivatives; 5-HT1D serotonin receptor; In vivo; Vertebrata; Mammalia; Guinea pig; Structure activity relation; Animal; Cross reaction; Neurotransmitter; Antagonist; Piperazine derivatives; Chemical synthesis; Diastereomer; Serotonin reuptake inhibitor; 5-HT1D antagonist