Growth hormone signaling and action in obese versus lean human subjects

• Published in: American journal of physiology: endocrinology and metabolism Vol. 316; no. 2; pp. E333 - E344
• Main Authors: Høgild, Morten Lyng, Bak, Ann Mosegaard, Pedersen, Steen Bønløkke, Rungby, Jørgen, Frystyk, Jan, Møller, Niels, Jessen, Niels, Jørgensen, Jens O. L.
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.02.2019
• Subjects: Calorimetry; Crossovers; Drug delivery systems; Fasting; Glucose; Glucose metabolism; Growth hormones; Human subjects; In vivo methods and tests; Insulin; Insulin resistance; Insulin-like growth factor I; Intravenous administration; Lipolysis; Metabolism; Muscles; Obesity; Pharmacokinetics; Pharmacology; Phosphorylation; Preservation; Sensitivity; Signal transduction; Signaling; Substrates; Transcription; IGF-I; growth hormone; fasting and insulin resistance; obesity

Growth hormone (GH) levels are blunted in obesity, but it is not known whether this relates to altered GH sensitivity and whether this influences the metabolic adaptation to fasting. Therefore, we investigated the effect of obesity on GH signal transduction and fasting-induced changes in GH action....