Differentiation of ion-associated and osmotically driven water transport in canine airways

• Published in: American journal of respiratory and critical care medicine Vol. 162; no. 5; pp. 1715 - 1722
• Main Authors: CHEN, Ben T, YEATES, Donovan B
• Format: Journal Article
• Language: English
• Published: New York, NY American Lung Association 01.11.2000
• Subjects: Aerosols; Air breathing; Animals; Biological and medical sciences; Biological Transport; Chlorides - metabolism; Dogs; Fundamental and applied biological sciences. Psychology; Humidity; Male; Mannitol - administration & dosage; Osmolar Concentration; Respiration, Artificial; Respiratory Mucosa - metabolism; Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics; Sodium - metabolism; Trachea - metabolism; Vertebrates: respiratory system; Water - metabolism; Water; Fissipedia; Carnivora; Respiratory epithelium; Ion transport; Exploration; Osmosis; Experimental study; Respiratory system; Respiratory tract; Vertebrata; Mammalia; Air humidification; Animal; Chlorides; Sodium ion; Transport; Dog; Mechanical ventilation

We hypothesized that water transport associated with fluxes of Na(+) and Cl(-) across airway epithelium coexists and is distinct from osmotically driven water transport. To investigate this, we anesthetized and mechanically ventilated dogs (n = 8) with warm humid air. The trachea of each dog was seq...