An in vitro-transcribed circular RNA targets the mitochondrial inner membrane cardiolipin to ablate EIF4G2 + /PTBP1 + pan-adenocarcinoma

• Published in: Nature cancer Vol. 5; no. 1; pp. 30 - 46
• Main Authors: Feng, Zunyong, Zhang, Xuanbo, Zhou, Jing, Li, Qiang, Chu, Liuxi, Di, Guangfu, Xu, Zhengyuan, Chen, Qun, Wang, Ming, Jiang, Xiaochun, Xia, Hongping, Chen, Xiaoyuan
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.01.2024
• Subjects: Apoptosis; Cancer; Cell culture; Lipids; Medical prognosis; Nanoparticles; Plasmids; Proteins; Survival analysis; Toxicity; Tumors; Variance analysis

In vitro-transcribed (IVT) mRNA has arisen as a rapid method for the production of nucleic acid drugs. Here, we have constructed an oncolytic IVT mRNA that utilizes human rhinovirus type 2 (HRV2) internal ribosomal entry sites (IRESs) to selectively trigger translation in cancer cells with high expr...