Urokinase-type plasminogen activator negatively regulates α-smooth muscle actin expression via Endo180 and the uPA receptor in corneal fibroblasts

• Published in: American Journal of Physiology: Cell Physiology Vol. 323; no. 1; pp. C104 - C115
• Main Authors: Sugioka, Koji, Nishida, Teruo, Kodama-Takahashi, Aya, Murakami, Junko, Mano, Fukutaro, Okada, Kiyotaka, Fukuda, Masahiko, Kusaka, Shunji
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.07.2022
• Subjects: Actin; Cell culture; Collagen; Collagen (type I); Cornea; Extracellular matrix; Fibroblasts; Phosphorylation; Proteoglycans; Smad3 protein; Smooth muscle; Stroma; Thrombolytic drugs; Transforming growth factor-b; U-Plasminogen activator; Wound healing; collagen; corneal myofibroblast; urokinase-type plasminogen activator receptor (uPAR); Endo180; urokinase-type plasminogen activator (uPA)

Corneal fibroblasts are embedded within an extracellular matrix composed largely of collagen type 1, proteoglycans, and other proteins in the corneal stroma, and their morphology and function are subject to continuous regulation by collagen. During wound healing and in various pathological condition...