Importance of sympathetic activation for the expression of Na+-Ca2+ exchanger in end-stage failing human myocardium

• Published in: European heart journal Vol. 23; no. 14; pp. 1118 - 1124
• Main Authors: Schillinger, W., Schneider, H., Minami, K., Ferrari, R., Hasenfuss, G.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.07.2002
• Subjects: Arrhythmia; Biological and medical sciences; Biological Transport; calcium; Cardiac Catheterization; Cardiology. Vascular system; Case-Control Studies; catecholamines; Catecholamines - analysis; Catecholamines - biosynthesis; Cohort Studies; Electrocardiography, Ambulatory; Female; Heart; heart failure; Heart Failure - diagnosis; Heart Failure - enzymology; Heart Failure - surgery; Heart failure, cardiogenic pulmonary edema, cardiac enlargement; Heart Transplantation; Humans; Male; Medical sciences; Middle Aged; myocardium; Myocardium - enzymology; Na+-Ca2+-exchanger; Preoperative Care; Probability; Reference Values; Severity of Illness Index; Sodium-Potassium-Exchanging ATPase - analysis; Sodium-Potassium-Exchanging ATPase - metabolism; Sympathetic Nervous System - physiology; Human; Heart failure; Calcium ion; Pathogenesis; Heart disease; Sodium ion; Cardiovascular disease; Ion exchanger; Terminal stage; Catecholamine; Sympathetic nervous system

Aims In end-stage heart failure, an alteration in the expression of the Na+-Ca2+ exchanger has been reported. Regulation of its expression is largely unknown. We sought to find out whether Na+-Ca2+ exchanger in human heart failure is regulated by sympathetic activation. In addition, since Na+-Ca2+-e...