Workshop on treatment of and postexposure prophylaxis for Burkholderia pseudomallei and B. mallei Infection, 2010
The US Public Health Emergency Medical Countermeasures Enterprise convened subject matter experts at the 2010 HHS Burkholderia Workshop to develop consensus recommendations for postexposure prophylaxis against and treatment for Burkholderia pseudomallei and B. mallei infections, which cause melioido...
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Published in | Emerging infectious diseases Vol. 18; no. 12; p. e2 |
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Main Authors | , , , , , , , , , , , , , , , , , , , , , , , |
Format | Journal Article Conference Proceeding |
Language | English |
Published |
United States
Centers for Disease Control and Prevention
01.12.2012
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Abstract | The US Public Health Emergency Medical Countermeasures Enterprise convened subject matter experts at the 2010 HHS Burkholderia Workshop to develop consensus recommendations for postexposure prophylaxis against and treatment for Burkholderia pseudomallei and B. mallei infections, which cause melioidosis and glanders, respectively. Drugs recommended by consensus of the participants are ceftazidime or meropenem for initial intensive therapy, and trimethoprim/sulfamethoxazole or amoxicillin/clavulanic acid for eradication therapy. For postexposure prophylaxis, recommended drugs are trimethoprim/sulfamethoxazole or co-amoxiclav. To improve the timely diagnosis of melioidosis and glanders, further development and wide distribution of rapid diagnostic assays were also recommended. Standardized animal models and B. pseudomallei strains are needed for further development of therapeutic options. Training for laboratory technicians and physicians would facilitate better diagnosis and treatment options. |
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AbstractList | The US Public Health Emergency Medical Countermeasures Enterprise convened subject matter experts at the 2010 HHS Burkholderia Workshop to develop consensus recommendations for postexposure prophylaxis against and treatment for Burkholderia pseudomallei and B. mallei infections, which cause melioidosis and glanders, respectively. Drugs recommended by consensus of the participants are ceftazidime or meropenem for initial intensive therapy, and trimethoprim/sulfamethoxazole or amoxicillin/clavulanic acid for eradication therapy. For postexposure prophylaxis, recommended drugs are trimethoprim/sulfamethoxazole or co-amoxiclav. To improve the timely diagnosis of melioidosis and glanders, further development and wide distribution of rapid diagnostic assays were also recommended. Standardized animal models and B. pseudomallei strains are needed for further development of therapeutic options. Training for laboratory technicians and physicians would facilitate better diagnosis and treatment options. The US Public Health Emergency Medical Countermeasures Enterprise convened subject matter experts at the 2010 HHS Burkholderia Workshop to develop consensus recommendations for postexposure prophylaxis against and treatment for Burkholderia pseudomallei and B. mallei infections, which cause melioidosis and glanders, respectively. Drugs recommended by consensus of the participants are ceftazidime or meropenem for initial intensive therapy, and trimethoprim/sulfamethoxazole or amoxicillin/clavulanic acid for eradication therapy. For postexposure prophylaxis, recommended drugs are trimethoprim/sulfamethoxazole or co-amoxiclav. To improve the timely diagnosis of melioidosis and glanders, further development and wide distribution of rapid diagnostic assays were also recommended. Standardized animal models and B. pseudomallei strains are needed for further development of therapeutic options. Training for laboratory technicians and physicians would facilitate better diagnosis and treatment options. |
Author | Dance, David Smith, Theresa L Wuthiekanun, Vanaporn Pesik, Nicki Larsen, Joseph Garges, Susan Currie, Bart J Norton, Robert Lipsitz, Rebecca Schweizer, Herbert P Blaney, David D Wiersinga, W Joost Gee, Jay E Morrow, Meredith G O'Mara, Elizabeth Tan, Patrick Steinmetz, Ivo Cheng, Allen C Peacock, Sharon J Rogers, L Paige Baccam, Prasith Aurigemma, Rosemarie Limmathurotsakul, Direk Tan, Gladys |
Author_xml | – sequence: 1 givenname: Rebecca surname: Lipsitz fullname: Lipsitz, Rebecca – sequence: 2 givenname: Susan surname: Garges fullname: Garges, Susan – sequence: 3 givenname: Rosemarie surname: Aurigemma fullname: Aurigemma, Rosemarie – sequence: 4 givenname: Prasith surname: Baccam fullname: Baccam, Prasith – sequence: 5 givenname: David D surname: Blaney fullname: Blaney, David D – sequence: 6 givenname: Allen C surname: Cheng fullname: Cheng, Allen C – sequence: 7 givenname: Bart J surname: Currie fullname: Currie, Bart J – sequence: 8 givenname: David surname: Dance fullname: Dance, David – sequence: 9 givenname: Jay E surname: Gee fullname: Gee, Jay E – sequence: 10 givenname: Joseph surname: Larsen fullname: Larsen, Joseph – sequence: 11 givenname: Direk surname: Limmathurotsakul fullname: Limmathurotsakul, Direk – sequence: 12 givenname: Meredith G surname: Morrow fullname: Morrow, Meredith G – sequence: 13 givenname: Robert surname: Norton fullname: Norton, Robert – sequence: 14 givenname: Elizabeth surname: O'Mara fullname: O'Mara, Elizabeth – sequence: 15 givenname: Sharon J surname: Peacock fullname: Peacock, Sharon J – sequence: 16 givenname: Nicki surname: Pesik fullname: Pesik, Nicki – sequence: 17 givenname: L Paige surname: Rogers fullname: Rogers, L Paige – sequence: 18 givenname: Herbert P surname: Schweizer fullname: Schweizer, Herbert P – sequence: 19 givenname: Ivo surname: Steinmetz fullname: Steinmetz, Ivo – sequence: 20 givenname: Gladys surname: Tan fullname: Tan, Gladys – sequence: 21 givenname: Patrick surname: Tan fullname: Tan, Patrick – sequence: 22 givenname: W Joost surname: Wiersinga fullname: Wiersinga, W Joost – sequence: 23 givenname: Vanaporn surname: Wuthiekanun fullname: Wuthiekanun, Vanaporn – sequence: 24 givenname: Theresa L surname: Smith fullname: Smith, Theresa L |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23171644$$D View this record in MEDLINE/PubMed |
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Snippet | The US Public Health Emergency Medical Countermeasures Enterprise convened subject matter experts at the 2010 HHS Burkholderia Workshop to develop consensus... The US Public Health Emergency Medical Countermeasures Enterprise convened subject matter experts at the 2010 HHS Burkholderia Workshop to develop consensus... |
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SubjectTerms | Amoxicillin-Potassium Clavulanate Combination - administration & dosage Animals Anti-Bacterial Agents - administration & dosage Burkholderia mallei Burkholderia mallei - pathogenicity Burkholderia pseudomallei Burkholderia pseudomallei - pathogenicity Ceftazidime - administration & dosage Disease Models, Animal Disease Susceptibility drug therapy glanders Glanders - diagnosis Glanders - drug therapy Glanders - prevention & control Humans melioidosis Melioidosis - diagnosis Melioidosis - drug therapy Melioidosis - prevention & control Online Report Post-Exposure Prophylaxis - methods postexposure prophylaxis Risk Factors Thienamycins - administration & dosage Trimethoprim, Sulfamethoxazole Drug Combination - administration & dosage |
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Title | Workshop on treatment of and postexposure prophylaxis for Burkholderia pseudomallei and B. mallei Infection, 2010 |
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