Workshop on treatment of and postexposure prophylaxis for Burkholderia pseudomallei and B. mallei Infection, 2010

The US Public Health Emergency Medical Countermeasures Enterprise convened subject matter experts at the 2010 HHS Burkholderia Workshop to develop consensus recommendations for postexposure prophylaxis against and treatment for Burkholderia pseudomallei and B. mallei infections, which cause melioido...

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Published inEmerging infectious diseases Vol. 18; no. 12; p. e2
Main Authors Lipsitz, Rebecca, Garges, Susan, Aurigemma, Rosemarie, Baccam, Prasith, Blaney, David D, Cheng, Allen C, Currie, Bart J, Dance, David, Gee, Jay E, Larsen, Joseph, Limmathurotsakul, Direk, Morrow, Meredith G, Norton, Robert, O'Mara, Elizabeth, Peacock, Sharon J, Pesik, Nicki, Rogers, L Paige, Schweizer, Herbert P, Steinmetz, Ivo, Tan, Gladys, Tan, Patrick, Wiersinga, W Joost, Wuthiekanun, Vanaporn, Smith, Theresa L
Format Journal Article Conference Proceeding
LanguageEnglish
Published United States Centers for Disease Control and Prevention 01.12.2012
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Abstract The US Public Health Emergency Medical Countermeasures Enterprise convened subject matter experts at the 2010 HHS Burkholderia Workshop to develop consensus recommendations for postexposure prophylaxis against and treatment for Burkholderia pseudomallei and B. mallei infections, which cause melioidosis and glanders, respectively. Drugs recommended by consensus of the participants are ceftazidime or meropenem for initial intensive therapy, and trimethoprim/sulfamethoxazole or amoxicillin/clavulanic acid for eradication therapy. For postexposure prophylaxis, recommended drugs are trimethoprim/sulfamethoxazole or co-amoxiclav. To improve the timely diagnosis of melioidosis and glanders, further development and wide distribution of rapid diagnostic assays were also recommended. Standardized animal models and B. pseudomallei strains are needed for further development of therapeutic options. Training for laboratory technicians and physicians would facilitate better diagnosis and treatment options.
AbstractList The US Public Health Emergency Medical Countermeasures Enterprise convened subject matter experts at the 2010 HHS Burkholderia Workshop to develop consensus recommendations for postexposure prophylaxis against and treatment for Burkholderia pseudomallei and B. mallei infections, which cause melioidosis and glanders, respectively. Drugs recommended by consensus of the participants are ceftazidime or meropenem for initial intensive therapy, and trimethoprim/sulfamethoxazole or amoxicillin/clavulanic acid for eradication therapy. For postexposure prophylaxis, recommended drugs are trimethoprim/sulfamethoxazole or co-amoxiclav. To improve the timely diagnosis of melioidosis and glanders, further development and wide distribution of rapid diagnostic assays were also recommended. Standardized animal models and B. pseudomallei strains are needed for further development of therapeutic options. Training for laboratory technicians and physicians would facilitate better diagnosis and treatment options.
The US Public Health Emergency Medical Countermeasures Enterprise convened subject matter experts at the 2010 HHS Burkholderia Workshop to develop consensus recommendations for postexposure prophylaxis against and treatment for Burkholderia pseudomallei and B. mallei infections, which cause melioidosis and glanders, respectively. Drugs recommended by consensus of the participants are ceftazidime or meropenem for initial intensive therapy, and trimethoprim/sulfamethoxazole or amoxicillin/clavulanic acid for eradication therapy. For postexposure prophylaxis, recommended drugs are trimethoprim/sulfamethoxazole or co-amoxiclav. To improve the timely diagnosis of melioidosis and glanders, further development and wide distribution of rapid diagnostic assays were also recommended. Standardized animal models and B. pseudomallei strains are needed for further development of therapeutic options. Training for laboratory technicians and physicians would facilitate better diagnosis and treatment options.
Author Dance, David
Smith, Theresa L
Wuthiekanun, Vanaporn
Pesik, Nicki
Larsen, Joseph
Garges, Susan
Currie, Bart J
Norton, Robert
Lipsitz, Rebecca
Schweizer, Herbert P
Blaney, David D
Wiersinga, W Joost
Gee, Jay E
Morrow, Meredith G
O'Mara, Elizabeth
Tan, Patrick
Steinmetz, Ivo
Cheng, Allen C
Peacock, Sharon J
Rogers, L Paige
Baccam, Prasith
Aurigemma, Rosemarie
Limmathurotsakul, Direk
Tan, Gladys
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  start-page: 674
  year: 2008
  ident: key-10.3201/eid1812.120638-201211201240-R43
  article-title: Pre- and post-exposure prophyalxis of experimental Burkholderia pseudomallei infection with doxycycline, amoxicillin/calvulanic acid and co-trimoxazole.
  publication-title: J Antimicrob Chemother
  doi: 10.1093/jac/dkm527
  contributor:
    fullname: Sivalingam
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Snippet The US Public Health Emergency Medical Countermeasures Enterprise convened subject matter experts at the 2010 HHS Burkholderia Workshop to develop consensus...
The US Public Health Emergency Medical Countermeasures Enterprise convened subject matter experts at the 2010 HHS Burkholderia Workshop to develop consensus...
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SubjectTerms Amoxicillin-Potassium Clavulanate Combination - administration & dosage
Animals
Anti-Bacterial Agents - administration & dosage
Burkholderia mallei
Burkholderia mallei - pathogenicity
Burkholderia pseudomallei
Burkholderia pseudomallei - pathogenicity
Ceftazidime - administration & dosage
Disease Models, Animal
Disease Susceptibility
drug therapy
glanders
Glanders - diagnosis
Glanders - drug therapy
Glanders - prevention & control
Humans
melioidosis
Melioidosis - diagnosis
Melioidosis - drug therapy
Melioidosis - prevention & control
Online Report
Post-Exposure Prophylaxis - methods
postexposure prophylaxis
Risk Factors
Thienamycins - administration & dosage
Trimethoprim, Sulfamethoxazole Drug Combination - administration & dosage
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Title Workshop on treatment of and postexposure prophylaxis for Burkholderia pseudomallei and B. mallei Infection, 2010
URI https://www.ncbi.nlm.nih.gov/pubmed/23171644
https://search.proquest.com/docview/1197483682
https://pubmed.ncbi.nlm.nih.gov/PMC3557896
https://doaj.org/article/5202ba97436b4303bc57bfb60f85d843
Volume 18
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