IL-25 Receptor Expression on Airway Dendritic Cells after Allergen Challenge in Subjects with Asthma

• Published in: American journal of respiratory and critical care medicine Vol. 193; no. 9; pp. 957 - 964
• Main Authors: Tworek, Damian, Smith, Steven G, Salter, Brittany M, Baatjes, Adrian J, Scime, Tara, Watson, Rick, Obminski, Caitlin, Gauvreau, Gail M, O'Byrne, Paul M
• Format: Journal Article
• Language: English
• Published: United States American Thoracic Society 01.05.2016
• Subjects: Administration, Inhalation; Adolescent; Adult; Aged; Allergens - administration & dosage; Allergens - immunology; Allergens - metabolism; Asthma - immunology; Asthma - metabolism; Bronchial Provocation Tests - methods; Dendritic Cells - immunology; Dendritic Cells - metabolism; Female; Flow Cytometry; Humans; Male; Middle Aged; Receptors, Interleukin - immunology; Receptors, Interleukin - metabolism; Sputum - immunology; Young Adult; IL-17RB; TLR9; dendritic cells; allergic asthma

IL-25 is an epithelial-derived cytokine, whose effects are mediated by the IL-25 receptor (IL-17RB), and that has been implicated in the pathogenesis of allergic disease and airway viral responses. Airway myeloid dendritic cells (mDCs) and plasmacytoid dendritic cells (pDCs) are professional antigen...