Analysis of sleep deprivation-associated Homer1 gene and protein acting on synaptic plasticity by bioinformatics and animal experiments

• Published in: ANESTHESIOLOGY AND PERIOPERATIVE SCIENCE Vol. 1; no. 1; pp. 1 - 14
• Main Authors: Li, Yun, Zhao, Lina, Zhou, Qi, Zhang, Xizhe, Song, Jiannan, Wang, Xinyi, Yang, Chenyi, Wang, Haiyun
• Format: Journal Article
• Language: English
• Published: Singapore Springer Nature Singapore 13.03.2023; Springer
• Subjects: Anesthesiology; Critical Care Medicine; Differentially expressed genes; Enrichment analysis; Hippocampus; Homer1; Intensive; Medicine; Medicine & Public Health; Neurosciences; Original Research; Pharmacology/Toxicology; Protein–protein interactions network; Sleep deprivation; Surgery; Homer1; Differentially expressed genes; Synaptic plasticity; Enrichment analysis; Protein–protein interactions network; Sleep deprivation; Hippocampus

Background Homer1, an immediate early gene, is related to sleep deprivation (SD), and its protein products are involved in synaptic plasticity affecting the cognitive process. This study aimed to identify the SD-associated key Homer1 gene in the brain and explore the value of Homer1 proteins acting...