Mesenchymal condensation in tooth development and regeneration: a focus on translational aspects of organogenesis

• Published in: Physiological reviews Vol. 103; no. 3; pp. 1899 - 1964
• Main Authors: Sui, Bing-Dong, Zheng, Chen-Xi, Zhao, Wan-Min, Xuan, Kun, Li, Bei, Jin, Yan
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.07.2023
• Subjects: Animals; Bone Regeneration; Epithelium; Homeostasis; Humans; Inflammation; Mastication; Mesoderm - growth & development; Morphogenesis; Odontogenesis; Organogenesis; Pattern formation; Regenerative medicine; Teeth; Tissue engineering; Tissue Engineering - methods; Tooth - growth & development; Tooth Loss - therapy; stem cells; organogenesis; regeneration; mesenchymal condensation; tooth

The teeth are vertebrate-specific, highly specialized organs performing fundamental functions of mastication and speech, the maintenance of which is crucial for orofacial homeostasis and is further linked to systemic health and human psychosocial well-being. However, with limited ability for self-re...