Terahertz Microfluidic Metamaterial Biosensor for Sensitive Detection of Small-Volume Liquid Samples

Metamaterial (MM) assisted terahertz (THz) label-free biosensing has promising applications. However, the sensitive THz detection of highly absorptive liquid samples remains challenging. Here, we present a novel multi-microfluidic-channel MM biosensor for highly sensitive THz sensing of small-volume...

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Published inIEEE transactions on terahertz science and technology Vol. 9; no. 2; pp. 209 - 214
Main Authors Zhang, Rui, Chen, Qingming, Liu, Kai, Chen, Zefeng, Li, Kaidi, Zhang, Xuming, Xu, Jianbin, Pickwell-MacPherson, Emma
Format Journal Article
LanguageEnglish
Published IEEE 01.03.2019
Subjects
Biomedical spectroscopy
Liquids
metamaterial (MM)
Metamaterials
microfluidic
Microfluidics
Resists
Resonant frequency
Sensitivity
Sensors
terahertz (THz) spectroscopy
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Abstract Metamaterial (MM) assisted terahertz (THz) label-free biosensing has promising applications. However, the sensitive THz detection of highly absorptive liquid samples remains challenging. Here, we present a novel multi-microfluidic-channel MM biosensor for highly sensitive THz sensing of small-volume liquid samples. The multichannels are set mostly in the strong electric field enhancement area of the MM, which significantly decreases the liquid's amount and enhances the interaction between the sensing targets and the THz wave (thus increasing the sensitivity). The sensing results of isopropyl-alcohol-water mixtures and bovine serum albumin solutions based on the bow-tie array MM with multichannels demonstrate the effectiveness of the proposed design and the great potential in THz biosensing. This design has the advantages of being highly sensitive, label-free, cost-effective, easy to operate, and only needing a tiny liquid volume. Thus, our device provides a robust route for MM-assisted THz label-free biosensing of liquid-based substances.
AbstractList Metamaterial (MM) assisted terahertz (THz) label-free biosensing has promising applications. However, the sensitive THz detection of highly absorptive liquid samples remains challenging. Here, we present a novel multi-microfluidic-channel MM biosensor for highly sensitive THz sensing of small-volume liquid samples. The multichannels are set mostly in the strong electric field enhancement area of the MM, which significantly decreases the liquid's amount and enhances the interaction between the sensing targets and the THz wave (thus increasing the sensitivity). The sensing results of isopropyl-alcohol-water mixtures and bovine serum albumin solutions based on the bow-tie array MM with multichannels demonstrate the effectiveness of the proposed design and the great potential in THz biosensing. This design has the advantages of being highly sensitive, label-free, cost-effective, easy to operate, and only needing a tiny liquid volume. Thus, our device provides a robust route for MM-assisted THz label-free biosensing of liquid-based substances.
Author Zhang, Xuming
Xu, Jianbin
Chen, Zefeng
Chen, Qingming
Pickwell-MacPherson, Emma
Zhang, Rui
Liu, Kai
Li, Kaidi
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Snippet Metamaterial (MM) assisted terahertz (THz) label-free biosensing has promising applications. However, the sensitive THz detection of highly absorptive liquid...
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SubjectTerms Biomedical spectroscopy
Liquids
metamaterial (MM)
Metamaterials
microfluidic
Microfluidics
Resists
Resonant frequency
Sensitivity
Sensors
terahertz (THz) spectroscopy
Title Terahertz Microfluidic Metamaterial Biosensor for Sensitive Detection of Small-Volume Liquid Samples
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