Cg-TGF- β, a TGF- β/activin homologue in the Pacific Oyster Crassostrea gigas, is involved in immunity against Gram-negative microbial infection
Transforming growth factor- β (TGF- β) members represent a widespread protein superfamily in the animal kingdom, but few members have been characterised in lophotrochozoans, a major clade of invertebrates. Here, we report the identification of Crassostrea gigas-TGF- β (Cg-TGF- β), a homologue of ver...
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| Published in | Developmental & Comparative Immunology Vol. 31; no. 1; pp. 30 - 38 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Ltd
2007
Elsevier |
| Subjects | |
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| Abstract | Transforming growth factor-
β (TGF-
β) members represent a widespread protein superfamily in the animal kingdom, but few members have been characterised in lophotrochozoans, a major clade of invertebrates. Here, we report the identification of
Crassostrea gigas-TGF-
β (Cg-TGF-
β), a homologue of vertebrate TGF-
β and activin, from the bivalve mollusc
C. gigas. Phylogenetic analysis suggests an early ancestral origin of this subgroup of TGF-
β superfamily member. Investigation of the spatio–temporal expression of Cg-TGF-
β gene by real-time quantitative RT-PCR showed a ubiquitous pattern in all adult tissues. These findings imply that Cg-TGF-
β has multiple functions as described for its vertebrate counterparts. Moreover, Cg-TGF-
β was upregulated in haemocytes during infection by a Gram-negative bacterium, suggesting that it could act as a cytokine involved in immunity in molluscs. |
|---|---|
| AbstractList | Transforming growth factor- beta (TGF- beta ) members represent a widespread protein superfamily in the animal kingdom, but few members have been characterised in lophotrochozoans, a major clade of invertebrates. Here, we report the identification of Crassostrea gigas-TGF- beta (Cg-TGF- beta ), a homologue of vertebrate TGF- beta and activin, from the bivalve mollusc C. gigas. Phylogenetic analysis suggests an early ancestral origin of this subgroup of TGF- beta superfamily member. Investigation of the spatio-temporal expression of Cg-TGF- beta gene by real-time quantitative RT-PCR showed a ubiquitous pattern in all adult tissues. These findings imply that Cg-TGF- beta has multiple functions as described for its vertebrate counterparts. Moreover, Cg-TGF- beta was upregulated in haemocytes during infection by a Gram-negative bacterium, suggesting that it could act as a cytokine involved in immunity in molluscs. Transforming growth factor- β (TGF- β) members represent a widespread protein superfamily in the animal kingdom, but few members have been characterised in lophotrochozoans, a major clade of invertebrates. Here, we report the identification of Crassostrea gigas-TGF- β (Cg-TGF- β), a homologue of vertebrate TGF- β and activin, from the bivalve mollusc C. gigas. Phylogenetic analysis suggests an early ancestral origin of this subgroup of TGF- β superfamily member. Investigation of the spatio–temporal expression of Cg-TGF- β gene by real-time quantitative RT-PCR showed a ubiquitous pattern in all adult tissues. These findings imply that Cg-TGF- β has multiple functions as described for its vertebrate counterparts. Moreover, Cg-TGF- β was upregulated in haemocytes during infection by a Gram-negative bacterium, suggesting that it could act as a cytokine involved in immunity in molluscs. |
| Author | Badariotti, F. Lelong, C. Favrel, P. Dubos, M.P. Le Quéré, H. Rodet, F. |
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| Keywords | Transforming growth factor β Mollusc Immunity Crassostrea gigas Cytokine |
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β) members represent a widespread protein superfamily in the animal kingdom, but few members have been characterised in... Transforming growth factor-beta (TGF-beta) members represent a widespread protein superfamily in the animal kingdom, but few members have been characterised in... Transforming growth factor- beta (TGF- beta ) members represent a widespread protein superfamily in the animal kingdom, but few members have been characterised... |
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| SubjectTerms | Activins - genetics Activins - immunology Amino Acid Sequence Animals Bivalvia Crassostrea Crassostrea - immunology Crassostrea - microbiology Crassostrea gigas Cytokine Cytokines - immunology Gene Expression Regulation - immunology Gram-Negative Bacterial Infections - immunology Gram-Negative Bacterial Infections - veterinary Immunity Life Sciences Marine Molecular Sequence Data Mollusc Transforming Growth Factor beta - genetics Transforming Growth Factor beta - immunology Transforming growth factor β |
| Title | Cg-TGF- β, a TGF- β/activin homologue in the Pacific Oyster Crassostrea gigas, is involved in immunity against Gram-negative microbial infection |
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