The Cutaneous Basophil Response to Phytohemagglutinin in Chickens

A cellular infiltrate rich in basophils was observed in chickens in skin sites injected locally with the mitogen PHA. These infiltrating metachromatically granulated cells exhibited features common to mast cells of some species (monolobed nucleus), but also resembled basophils of other species in th...

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Bibliographic Details
Published inThe Journal of immunology (1950) Vol. 118; no. 5; pp. 1564 - 1568
Main Authors Stadecker, Miguel J, Lukic, Miodrag, Dvorak, Ann, Leskowitz, Sidney
Format Journal Article
LanguageEnglish
Published United States Am Assoc Immnol 01.05.1977
Subjects
Animals
Basophils - immunology
Basophils - pathology
Basophils - ultrastructure
Chickens
Hypersensitivity, Delayed - etiology
Hypersensitivity, Delayed - immunology
Hypersensitivity, Delayed - pathology
Lectins - pharmacology
T-Lymphocytes - immunology
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Summary:A cellular infiltrate rich in basophils was observed in chickens in skin sites injected locally with the mitogen PHA. These infiltrating metachromatically granulated cells exhibited features common to mast cells of some species (monolobed nucleus), but also resembled basophils of other species in that they circulated in the blood, and they responded to the PHA mitogen by infiltrating skin test sites. Previous literature suggests that the chicken has a single metachromatic granulated cell and our data support this notion. PHA, a known T cell mitogen, may act by causing the stimulated T lymphocyte to produce a lymphokine that is responsible for the attraction of basophils to the test site.
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ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.118.5.1564