Repeated Omicron exposures redirect SARS-CoV-2-specific memory B cell evolution toward the latest variants

• Published in: Science translational medicine Vol. 16; no. 761; p. eadp9927
• Main Authors: Kotaki, Ryutaro, Moriyama, Saya, Oishi, Shintaro, Onodera, Taishi, Adachi, Yu, Sasaki, Eita, Ishino, Kota, Morikawa, Miwa, Takei, Hiroaki, Takahashi, Hidenori, Takano, Tomohiro, Nishiyama, Ayae, Yumoto, Kohei, Terahara, Kazutaka, Isogawa, Masanori, Matsumura, Takayuki, Shinkai, Masaharu, Takahashi, Yoshimasa
• Format: Journal Article
• Language: English
• Published: United States 21.08.2024
• Subjects: Antibodies, Neutralizing - immunology; Antibodies, Viral - immunology; COVID-19 - immunology; COVID-19 - virology; COVID-19 Vaccines - immunology; Humans; Memory B Cells - immunology; SARS-CoV-2 - immunology; Spike Glycoprotein, Coronavirus - genetics; Spike Glycoprotein, Coronavirus - immunology

Immunological imprinting by ancestral SARS-CoV-2 strains is thought to impede the robust induction of Omicron-specific humoral responses by Omicron-based booster vaccines. Here, we analyzed the specificity and neutralization activity of memory B (B ) cells after repeated BA.5 exposure in individuals...