Lung-Protective Mechanical Ventilation in Patients with Severe Acute Brain Injury: A Multicenter Randomized Clinical Trial (PROLABI)

• Published in: American journal of respiratory and critical care medicine Vol. 210; no. 9; pp. 1123 - 1131
• Main Authors: Mascia, Luciana, Fanelli, Vito, Mistretta, Alice, Filippini, Matteo, Zanin, Mattia, Berardino, Maurizio, Mazzeo, Anna Teresa, Caricato, Anselmo, Antonelli, Massimo, Della Corte, Francesco, Grossi, Francesca, Munari, Marina, Caravello, Massimiliano, Alessandri, Francesco, Cavalli, Irene, Mezzapesa, Mario, Silvestri, Lucia, Casartelli Liviero, Marilena, Zanatta, Paolo, Pelosi, Paolo, Citerio, Giuseppe, Filippini, Claudia, Rucci, Paola, Rasulo, Frank A., Tonetti, Tommaso
• Format: Journal Article
• Language: English
• Published: United States American Thoracic Society 01.11.2024
• Subjects: Adult; Aged; Brain Injuries - mortality; Brain Injuries - therapy; Clinical outcomes; Clinical trials; Female; Humans; Male; Middle Aged; Positive-Pressure Respiration - methods; Respiration, Artificial - methods; Respiratory distress syndrome; Respiratory Distress Syndrome - therapy; Tidal Volume; Traumatic brain injury; Treatment Outcome; Ventilators; lung-protective ventilation; acute respiratory distress syndrome; acute brain injury

Lung-protective strategies using low Vt and moderate positive end-expiratory pressure (PEEP) are considered best practice in critical care, but interventional trials have never been conducted in patients with acute brain injuries because of concerns about carbon dioxide control and the effect of PEE...