Synthesis of Novel Spiro Thiazolotriazole Derivatives via 1,3-Dipolar Cycloaddition of Azomethine Ylide

• Published in: Journal of heterocyclic chemistry Vol. 49; no. 5; pp. 1050 - 1053
• Main Authors: Xiaofang, Li, Bin, Liu, Haochong, Liu, Xianyong, Yu, Pinggui, Yi
• Format: Journal Article
• Language: English
• Published: HOBOKEN Blackwell Publishing Ltd 01.09.2012; Wiley; Wiley Subscription Services, Inc
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; Spectrum analysis; REGIOSELECTIVE-SYNTHESIS; PYRIDO-PYRROLIZINES; STEREOSELECTIVE-SYNTHESIS; DISCOVERY; NITRILE OXIDE

The 1,3‐dipolar cycloaddition of azomethine ylide generated in situ from isatin and sarcosine to 5‐arylmethylidene thiazolo[3,2‐b][1,2,4]triazol‐6(5H)‐ones afforded novel 1′‐methyl‐4′‐aryldispiro[indole‐3,2′‐pyrrolidine‐3′,5″‐[1,3]thiazolo[3,2‐b][1,2,4]triazole]‐2,6″ (1H)‐diones in moderate yields....