Botryosphaeran and sulfonated derivatives as novel antiviral agents for herpes simplex and dengue fever

• Published in: International journal of biological macromolecules Vol. 138; pp. 334 - 339
• Main Authors: Sacchelli, Bruce Alan Lobo, Faccin-Galhardi, Ligia Carla, Ito, Vitor Yuji, Lopes, José Louzinho, Dekker, Robert F.H., Barbosa-Dekker, Aneli M., Orsato, Alexandre
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2019
• Subjects: (1 → 3)(1 → 6)-β-d-Glucan; Animals; Antiviral Agents - chemistry; Antiviral Agents - pharmacology; Antivirals; Botryosphaeria rhodina MAMB-05; Chlorocebus aethiops; Dengue Virus - drug effects; Glucans - chemistry; Glucans - pharmacology; Poliovirus - drug effects; Simplexvirus - drug effects; Sulfated polysaccharides; Sulfonic Acids - chemistry; Vero Cells; Sulfated polysaccharides; Botryosphaeria rhodina MAMB-05; (1 → 3)(1 → 6)-β-d-Glucan; Antivirals

Sulfated polysaccharides are known to display activity against enveloped viruses, such as herpes and dengue. The aim of this work was to assess the antiviral activity of botryosphaeran, a fungal exocellular (1 → 3)(1 → 6)-β-d-glucan devoid of sulfate groups, and its chemically sulfonated derivatives...