Longitudinal brain imaging in preclinical Alzheimer disease: impact of APOE ε4 genotype

• Published in: Brain (London, England : 1878) Vol. 141; no. 6; pp. 1828 - 1839
• Main Authors: Mishra, Shruti, Blazey, Tyler M, Holtzman, David M, Cruchaga, Carlos, Su, Yi, Morris, John C, Benzinger, Tammie L S, Gordon, Brian A
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.06.2018
• Subjects: Adult; Aged; Aged, 80 and over; Alzheimer Disease - diagnostic imaging; Alzheimer Disease - genetics; Amyloid beta-Peptides - metabolism; Aniline Compounds - metabolism; Apolipoprotein E4 - genetics; Brain - diagnostic imaging; Cross-Sectional Studies; Female; Genotype; Humans; Longitudinal Studies; Magnetic Resonance Imaging; Male; Middle Aged; Original; Positron-Emission Tomography; Thiazoles - metabolism; atrophy; apolipoprotein; amyloid; APOE; PET

The longitudinal impact of apolipoprotein E ɛ4 on individual disease trajectories remains unclear. Mishra et al. show that group level effects on atrophy and β-amyloid are driven by ɛ4 carriers being more likely to develop Alzheimer's disease, doing so earlier, and accumulating more β-amyloid e...