Incisional Negative Pressure Wound Therapy Decreases the Frequency of Postoperative Perineal Surgical Site Infections: A Cohort Study

• Published in: Diseases of the colon & rectum Vol. 57; no. 8; pp. 999 - 1006
• Main Authors: Chadi, Sami A, Kidane, Biniam, Britto, Karen, Brackstone, Muriel, Ott, Michael C
• Format: Journal Article
• Language: English
• Published: Hagerstown, MDc The American Society of Colon and Rectal Surgeons 01.08.2014; Lippincott Williams & Wilkins
• Subjects: Anus Neoplasms - pathology; Anus Neoplasms - surgery; Anus Neoplasms - therapy; Biological and medical sciences; Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - surgery; Carcinoma, Squamous Cell - therapy; Case-Control Studies; Female; Gastroenterology. Liver. Pancreas. Abdomen; General aspects; Human infectious diseases. Experimental studies and models; Humans; Infectious diseases; Male; Medical sciences; Middle Aged; Negative-Pressure Wound Therapy - methods; Neoadjuvant Therapy; Neoplasm Staging; Perineum; Rectal Neoplasms - pathology; Rectal Neoplasms - surgery; Rectal Neoplasms - therapy; Retrospective Studies; Risk Factors; Surgical Wound Infection - prevention & control; Postoperative; Nosocomial infection; Wound closure; Negative pressure; Abdominoperineal resection; Wound; Treatment; Surgery; Cohort study; Gastroenterology; Rectum; Colon; Colon and rectal surgery; Incisional negative pressure wound therapy
• DOI: 10.1097/DCR.0000000000000161
• ISSN: 0012-3706

BACKGROUND:Abdominoperineal resection is a procedure associated with high rates of perineal surgical site infections, causing distress to the patient, costs to the hospital system, and delays in further treatment. OBJECTIVE:The aim of this study was to investigate the role of incisional negative pressure wound therapy in decreasing the rates of perineal surgical site infection. DESIGN:This retrospective cohort study had a historical, consecutively sampled control group. SETTINGS:This study was conducted at a single-institution tertiary care academic institution. PATIENTS:All patients undergoing an abdominoperineal resection between 2008 and 2012 were assessed. INTERVENTIONS:Perineal incisional negative pressure wound therapy was applied to all patients following an abdominoperineal resection between 2010 and 2012 at 125 mmHg continuous suction for 5 days postoperatively. MAIN OUTCOME MEASURES:The development of a perineal surgical site infection within the first 30 days postoperatively was the primary outcome measured. RESULTS:Fifty-nine patients were included27 in the incisional negative pressure wound therapy group and 32 in the control group. A statistically lower proportion of perineal surgical site infections were detected in the incisional negative pressure wound therapy group than in the standard dressing group (15% vs 41%; p = 0.02). Both populations were similar in perioperative risk factors, with the exception of increased levels of blood urea nitrogen, a higher proportion of hypertensive patients, and a longer mean operative time in the incisional negative pressure wound therapy group. Additionally, an increased length of stay was observed in the incisional negative pressure wound therapy group (11 vs 8 days; p = 0.03). After adjusting for confounders, including the type of perineal dissection, incisional negative pressure wound therapy was found to be an independent predictor of not developing an surgical site infection (adjusted OR, 0.11; 95% CI, 0.04-0.66; p = 0.01). LIMITATIONS:The study’s retrospective nature limits the results because of the risk of interpreter bias, although this was addressed in part by reviewing data in duplicate. We controlled for the potential for selection bias with our consecutive sampling model. CONCLUSIONS:Our study demonstrates a role for incisional negative pressure wound therapy in decreasing rates of perineal surgical site infection following abdominoperineal resection. Prospective randomized trials will be required to further investigate this intervention.