Effects of selective COX-2 inhibitors on the gastric permeability of sucrose: a controlled study with placebo and ibuprofen
Acute and chronic use of non-steroidal anti-inflammatory drugs can increase gastrointestinal permeability. Celecoxib, which selectively inhibits the enzyme cyclooxygenase-2, is a novel anti-inflammatory drug with minimal gastrointestinal toxic effects while retaining anti-inflammatory efficacy. Our...
Saved in:
Published in | European journal of gastroenterology & hepatology Vol. 15; no. 4; p. 403 |
---|---|
Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
01.04.2003
|
Subjects | |
Online Access | Get more information |
Cover
Loading…
Abstract | Acute and chronic use of non-steroidal anti-inflammatory drugs can increase gastrointestinal permeability. Celecoxib, which selectively inhibits the enzyme cyclooxygenase-2, is a novel anti-inflammatory drug with minimal gastrointestinal toxic effects while retaining anti-inflammatory efficacy. Our aim was to assess the potential effects of celecoxib on gastric permeability in comparison with placebo and ibuprofen.
We conducted a prospective, double-blind, cross-over study.
This study is carried out at Marmara University Hospital.
Twenty-five healthy subjects entered the study but 19 subjects completed the treatment.
Subjects were randomized to celecoxib 100 mg twice daily, ibuprofen 600 mg twice daily or placebo for 7 days in pre-defined sequences. Treatments were separated by a 7 day washout period.
Gastric permeability was assessed by measuring urinary excretion of sucrose spectrophotometrically.
Ibuprofen 600 mg twice daily produced greater increases in gastric permeability compared with placebo or celecoxib (geometric mean of urinary sucrose recovery was 59.15, 32.65 and 33.11 mg/h for ibuprofen, placebo and celecoxib, respectively) (P < 0.001). Celecoxib was generally better tolerated than ibuprofen.
When compared with ibuprofen, celecoxib 100 mg twice daily has no significant effect on gastric mucosa in healthy subjects. |
---|---|
AbstractList | Acute and chronic use of non-steroidal anti-inflammatory drugs can increase gastrointestinal permeability. Celecoxib, which selectively inhibits the enzyme cyclooxygenase-2, is a novel anti-inflammatory drug with minimal gastrointestinal toxic effects while retaining anti-inflammatory efficacy. Our aim was to assess the potential effects of celecoxib on gastric permeability in comparison with placebo and ibuprofen.
We conducted a prospective, double-blind, cross-over study.
This study is carried out at Marmara University Hospital.
Twenty-five healthy subjects entered the study but 19 subjects completed the treatment.
Subjects were randomized to celecoxib 100 mg twice daily, ibuprofen 600 mg twice daily or placebo for 7 days in pre-defined sequences. Treatments were separated by a 7 day washout period.
Gastric permeability was assessed by measuring urinary excretion of sucrose spectrophotometrically.
Ibuprofen 600 mg twice daily produced greater increases in gastric permeability compared with placebo or celecoxib (geometric mean of urinary sucrose recovery was 59.15, 32.65 and 33.11 mg/h for ibuprofen, placebo and celecoxib, respectively) (P < 0.001). Celecoxib was generally better tolerated than ibuprofen.
When compared with ibuprofen, celecoxib 100 mg twice daily has no significant effect on gastric mucosa in healthy subjects. |
Author | Kocakaya, Ozan Ekenel, Meltem Imeryüz, Neşe Yüksel, Meral Haklar, Goncagül Avşar, Erol Tözün, Nurdan |
Author_xml | – sequence: 1 givenname: Meltem surname: Ekenel fullname: Ekenel, Meltem organization: Department of Internal Medicine, Marmara University Faculty of Medicine, Istanbul, Turkey – sequence: 2 givenname: Erol surname: Avşar fullname: Avşar, Erol – sequence: 3 givenname: Neşe surname: Imeryüz fullname: Imeryüz, Neşe – sequence: 4 givenname: Meral surname: Yüksel fullname: Yüksel, Meral – sequence: 5 givenname: Goncagül surname: Haklar fullname: Haklar, Goncagül – sequence: 6 givenname: Ozan surname: Kocakaya fullname: Kocakaya, Ozan – sequence: 7 givenname: Nurdan surname: Tözün fullname: Tözün, Nurdan |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/12655261$$D View this record in MEDLINE/PubMed |
BookMark | eNo1UMlOwzAQ9aGIlsIvoPmBgMdO4pgbqsoiVeoFpN4q23GoUWpHtgOq-HkilsNo5s1bpJkLMvPBW0IA6Q1SKW4ppSUTXBSMUk7LCRZTIc7IgsqqLGqJuzm5SOl92gqO4pzMkdVVxWpckK9111mTE4QOku2n0X1YWG13BQPnD067HOLEesgHC28q5egMDDYerdKud_n04xxNDMnegQITfI6h720LKY_tCT5dPsDQK2N1AOVbcHocYuisvyRnneqTvfrrS_L6sH5ZPRWb7ePz6n5TGM4RC1WbppTSoEBqjGKtNJzWglotK9twNmmqUujGVNNZAnldCpQNk7zlusa2ZEty_Zs7jPpo2_0Q3VHF0_7_C-wbP_ZgOg |
ContentType | Journal Article |
DBID | CGR CUY CVF ECM EIF NPM |
DOI | 10.1097/00042737-200304000-00011 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) |
DatabaseTitleList | MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | no_fulltext_linktorsrc |
Discipline | Medicine |
ExternalDocumentID | 12655261 |
Genre | Comparative Study Clinical Trial Randomized Controlled Trial Journal Article |
GroupedDBID | --- .-D .Z2 0R~ 4Q1 4Q2 4Q3 53G 5GY 5VS 6PF 71W 8L- AAAAV AAHPQ AAIQE AAMTA AARTV AASCR AAUEB AAWTL AAYEP ABASU ABBUW ABDIG ABJNI ABOCM ABVCZ ABXVJ ABZAD ACCJW ACDDN ACEWG ACGFO ACGFS ACILI ACWDW ACWRI ACXJB ACXNZ ADFPA ADGGA ADHPY ADNKB AE3 AE6 AEETU AENEX AFDTB AFSOK AFUWQ AGINI AHQNM AHVBC AINUH AJIOK AJNWD AJNYG AJZMW ALMA_UNASSIGNED_HOLDINGS ALMTX AMJPA AMKUR AMNEI AOHHW AWKKM BQLVK BS7 C45 CAG CGR COF CS3 CUY CVF DIWNM DUNZO E.X EBS ECM EEVPB EIF EJD EX3 F5P FCALG FL- GNXGY GQDEL H0~ HLJTE HZ~ IKREB IN~ IPNFZ JF9 JG8 JK3 JK8 K8S KD2 L-C N9A NPM N~M O9- OAG OAH OCUKA ODA OJAPA OLG OLW OPUJH ORVUJ OUVQU OVD OVDNE OVOZU OWU OWV OWW OWX OWY OWZ OXXIT P-K P2P R58 RIG RLZ S4R S4S T8P TEORI TSPGW V2I VVN W3M WOQ WOW X3V X3W XXN XYM YFH ZFV ZZMQN |
ID | FETCH-LOGICAL-c3311-a6c8499c1710cca2d9c30670eb95e832311547b8c5126713647198293d3b61d42 |
ISSN | 0954-691X |
IngestDate | Sat Sep 28 08:39:28 EDT 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 4 |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c3311-a6c8499c1710cca2d9c30670eb95e832311547b8c5126713647198293d3b61d42 |
PMID | 12655261 |
ParticipantIDs | pubmed_primary_12655261 |
PublicationCentury | 2000 |
PublicationDate | 2003-April |
PublicationDateYYYYMMDD | 2003-04-01 |
PublicationDate_xml | – month: 04 year: 2003 text: 2003-April |
PublicationDecade | 2000 |
PublicationPlace | England |
PublicationPlace_xml | – name: England |
PublicationTitle | European journal of gastroenterology & hepatology |
PublicationTitleAlternate | Eur J Gastroenterol Hepatol |
PublicationYear | 2003 |
SSID | ssj0017317 |
Score | 1.7118523 |
Snippet | Acute and chronic use of non-steroidal anti-inflammatory drugs can increase gastrointestinal permeability. Celecoxib, which selectively inhibits the enzyme... |
SourceID | pubmed |
SourceType | Index Database |
StartPage | 403 |
SubjectTerms | Adult Anti-Inflammatory Agents, Non-Steroidal - adverse effects Anti-Inflammatory Agents, Non-Steroidal - pharmacology Celecoxib Cyclooxygenase 2 Double-Blind Method Gastric Mucosa - metabolism Humans Ibuprofen - adverse effects Ibuprofen - pharmacology Isoenzymes - antagonists & inhibitors Male Membrane Proteins Permeability Prospective Studies Prostaglandin-Endoperoxide Synthases Pyrazoles Stomach - drug effects Sucrose - pharmacokinetics Sucrose - urine Sulfonamides - adverse effects Sulfonamides - pharmacology |
Title | Effects of selective COX-2 inhibitors on the gastric permeability of sucrose: a controlled study with placebo and ibuprofen |
URI | https://www.ncbi.nlm.nih.gov/pubmed/12655261 |
Volume | 15 |
hasFullText | |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnZ1LbxMxEMetFCTEBfEu5SEf6KlalLW93l1uEKWqkBourRRO1drr0KjNbpUHEuVj8oWYGXsflCAVLqtonWwS-6fxeDz-D2NvwStOnRjmUTJTs0hlFjUglYlkZkor86KQBal9TvTRqfo0TaaDwc9e1tJmbd7Z663nSv5nVOEejCuekv2HkW0fCjfgNYwvXGGE4XqrMR53yRgrqmeDaUCjz9NIHMyr87mZUykdvx1w8LXAEh0WhYoXzqtz0-76aoMzpfOnnkPm-iW4oSQ86-O0lLhlar_RYDZY5zucINsW0w_-LX1fjZKfS6_zhJCdw-y3_i2SP74Aa0tx6GN32QSSkcBv-6NkPz_0CeBjn5biKV645Xfc4P84ouj3xPl3toh-8Y0Xq-a5y9CRTXRD9pJimjClinROZXU6i530yFQ986tIL-HPacHLDQ-psIhMkSGJxovO1Htb36PlakG4xEInidC3aL0h2N007bCdNEOjO8EAUtjYSiUVgW7_VkguCzqiW38e6tqGR95Y-5APdPKQPQiLF_7Bk_iIDVz1mN07DukZT9iPACSvZ7wFkhOQvAOS1xUHIHkAkveBpE96IN_zgnc4csKRI4484MgBR97i-JSdHo5PRkdRqO4RWSnjOCq0zWC5bWPwccGMiDK3uHwdOpMnDuYZlIFSqcksuKQ6jbHOQZxn4J2W0ui4VOIZu1PVldtlXMY2N7pIS13mKhMmSwtdinjorBNYwugFe-677ezKS7icNR2699eWl-x-x-MrdncGNsO9Bgd0bd7QkP4C5x1_ZQ |
link.rule.ids | 786 |
linkProvider | National Library of Medicine |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Effects+of+selective+COX-2+inhibitors+on+the+gastric+permeability+of+sucrose%3A+a+controlled+study+with+placebo+and+ibuprofen&rft.jtitle=European+journal+of+gastroenterology+%26+hepatology&rft.au=Ekenel%2C+Meltem&rft.au=Av%C5%9Far%2C+Erol&rft.au=Imery%C3%BCz%2C+Ne%C5%9Fe&rft.au=Y%C3%BCksel%2C+Meral&rft.date=2003-04-01&rft.issn=0954-691X&rft.volume=15&rft.issue=4&rft.spage=403&rft_id=info:doi/10.1097%2F00042737-200304000-00011&rft_id=info%3Apmid%2F12655261&rft_id=info%3Apmid%2F12655261&rft.externalDocID=12655261 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0954-691X&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0954-691X&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0954-691X&client=summon |