The establishment of LC-MS/MS assays-specific reference intervals for serum folates and its application in evaluating FA-supplemented folate deficiency patients: Appeals for a suitable and individualized supplementation

• Published in: Clinica chimica acta Vol. 537; pp. 96 - 104
• Main Authors: Liu, Zhenni, Jin, Lizi, Zhang, Jiangtao, Zhou, Weiyan, Zeng, Jie, Zhang, Tianjiao, Zhang, Chuanbao
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.12.2022
• Subjects: Folate deficiency; Folic acid; Fortification; Liquid chromatography-tandem mass spectrometry; Neural tube defects; Reference interval; Liquid chromatography-tandem mass spectrometry; Reference interval; Fortification; Neural tube defects; Folate deficiency; Folic acid

•LC-MS/MS assay-specific RIs were established for serum folates vitamers.•The potential over-usage of FA supplements was observed in folates deficiency patients.•The LC-MS/MS assay-specific folates RIs for the evaluation of individual nutrition conditions and over-dosage monitoring were recommended....