1,2,3-Triazole derivatives: synthesis, docking, cytotoxicity analysis and in vivo antimalarial activity

• Published in: Chemico-biological interactions Vol. 350; p. 109688
• Main Authors: Valério Lopes, Fernanda, Fazza Stroppa, Pedro Henrique, Marinho, Juliane Aparecida, Reis Soares, Roberta, de Azevedo Alves, Lara, Capriles Goliatt, Priscila Vanessa Zabala, Abramo, Clarice, David da Silva, Adilson
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.12.2021
• Subjects: 1,2,3-Triazoles compounds; Antimalarial activity; Cytotoxicity evaluation; Molecular docking; Plasmodium berghei; Antimalarial activity; Plasmodium berghei; Cytotoxicity evaluation; Molecular docking; 1,2,3-Triazoles compounds

Malaria remains one of the most important parasitic diseases in the world. The multidrug-resistant Plasmodium strains make the treatment currently available for malaria less effective. Therefore, the development of new drugs is necessary to overcome therapy resistance. Triazole derivatives exhibit s...