Evaluation of the Reference Tissue Models for PET and SPECT Benzodiazepine Binding Parameters

• Published in: NeuroImage (Orlando, Fla.) Vol. 17; no. 2; pp. 928 - 942
• Main Authors: Millet, Philippe, Graf, Christophe, Buck, Alfred, Walder, Bernard, Ibáñez, Vicente
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2002; Elsevier Limited
• Subjects: [ 11C]flumazenil; [ 123I]iomazenil; Adult; Algorithms; benzodiazepine receptors; Brain - diagnostic imaging; Brain Chemistry - physiology; Computer Simulation; Female; Flumazenil - analogs & derivatives; Humans; Image Interpretation, Computer-Assisted - methods; Image Processing, Computer-Assisted - methods; Iodine Radioisotopes; Ligands; Male; PET, SPECT; Pons - anatomy & histology; Pons - metabolism; Radiopharmaceuticals; Receptors, GABA-A - metabolism; Reference Standards; reference tissue methods; Reference Values; Tomography, Emission-Computed - statistics & numerical data; Tomography, Emission-Computed, Single-Photon - statistics & numerical data; [ 123I]iomazenil; PET, SPECT; [ 11C]flumazenil; benzodiazepine receptors; reference tissue methods

Recently, reference tissue methods have been proposed to estimate binding potential from PET data. A reference region without specifically bound ligand is used as an indirect input function to enable the expression of the time–concentration curve of a region of interest using a compartment model. Ho...