Cytotoxic and Antitumor Effects of Curzerene from Curcuma longa

• Published in: Planta medica Vol. 83; no. 1-02; p. 23
• Main Authors: Wang, Youdi, Li, Jiahong, Guo, Jiquan, Wang, Qiyou, Zhu, Shuguang, Gao, Siyuan, Yang, Chen, Wei, Min, Pan, Xuediao, Zhu, Wei, Ding, Dongmei, Gao, Ruiping, Zhang, Wei, Wang, Junye, Zang, Linquan
• Format: Journal Article
• Language: English
• Published: Germany 01.01.2017
• Subjects: Adenocarcinoma - drug therapy; Adenocarcinoma of Lung; Animals; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Apoptosis - drug effects; Cell Cycle - drug effects; Cell Line, Tumor; Cell Proliferation - drug effects; Curcuma - chemistry; Down-Regulation - drug effects; Female; Gene Expression Regulation, Neoplastic - drug effects; Glutathione Transferase - genetics; Glutathione Transferase - metabolism; Humans; Lung Neoplasms - drug therapy; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Plant Extracts - chemistry; Sesquiterpenes - chemistry; Sesquiterpenes - pharmacology; Xenograft Model Antitumor Assays

Curzerene is a sesquiterpene and component used in oriental medicine. It was originally isolated from the traditional Chinese herbal medicine rhizomes. In this study, anticancer activity of curzerene was examined in both and models. The result of the MTT assay showed that curzerene exhibited antipro...