Utility of 64-MSCT in assessing acute non-reperfused myocardial infarct size

• Published in: Journal of geriatric cardiology : JGC Vol. 10; no. 3; pp. 247 - 252
• Main Authors: Qu, Xin-Kai, Fang, Wei-Yi, Ye, Jian-Ding, Guan, Shao-Feng, Li, Ruo-Gu, Xu, Ying-Jia, Shen, Yan, Zhang, Min, Liu, Hua
• Format: Journal Article
• Language: English
• Published: China Department of Cardiology, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai 200030, China%Department of Radiology, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai 200030, China 01.09.2013; Science Press
• Subjects: Time-factors; Animal model; Acute non-reperfused myocardial infarction; Multi-slice computed tomography
• ISSN: 1671-5411
• DOI: 10.3969/j.issn.1671-5411.2013.03.007

Objective To evaluate the utility of multi-slice computed tomography (MSCT) in assessing acute non-reperfused myocardial infarct size. Methods Seven domestic pigs (mean weight 17.3 ± 1.9 kg) underwent ligation of the distal left anterior descending artery to establish a model of acute myocardial infarction (MI). MSCT and triphenyltetrazolium chloride (TTC) staining were performed two hours later. The following data were acquired and analyzed:MI volume (%), CT values of the infarcted region, left ventricular cavity and normal cardiac tissue at various scanning time-points (1, 5, 10, 15, 20 min after contrast injection). Results Using MSCT, the overall MI volume showed a time-dependent decrease, with a reduction of 28.87%after 20 min. The greatest reduction occurred at the 5 min time-point. In TTC staining, MI volume was 9.87%± 2.44%. When MI size, as determined by MSCT, was compared with that by TTC staining in Bland-Altman plots, there was a better agreement at 5, 10, and 15 min time-points at 1 and 20 min. Conclusions The study indicates that double-phase scanning examination using MSCT is a useful tool to assess MI size, and the optimal late-phase scanning time-point set within 5-15 min of contrast injection.