Apolipoprotein ε7 allele in memory complaints: insights through protein structure prediction

• Published in: Clinical interventions in aging Vol. 12; pp. 1095 - 1102
• Main Authors: Youn, Young Chul, Lim, Yong Kwan, Han, Su-Hyun, Giau, Vo Van, Lee, Mi-kyoung, Park, Kwang-Yeol, Kim, SangYun, Bagyinszky, Eva, An, Seong Soo, Kim, Hye Ryoun
• Format: Journal Article
• Language: English
• Published: Auckland Taylor & Francis Ltd 01.07.2017; Dove Medical Press
• Subjects: Alzheimer's disease; Apolipoprotein structure; Apolipoproteins; Cognitive ability; Dementia; Deoxyribonucleic acid; DNA; Family medical history; Health promotion; Hospitals; Laboratories; Lipids; Lipoproteins; Memory; Metabolism; Mutation; Neurology; NMR; Nuclear magnetic resonance; Original Research; Peptides; Polymorphism; Proteins; small vessel disease; University colleges; vascular cognitive impairment
• ISSN: 1178-1998; 1176-9092; 1178-1998
• DOI: 10.2147/CIA.S131172

Purpose: APOE ε7gene is a rare mutant form of APOE ε3. The mutation occurs in the lipid-binding domain of APOE. Based on the protein’s structure, APOE ε7is expected to function in lipid and β-amyloid metabolism, similar to APOE ε4. However, unlike that for APOE ε4, the mechanisms responsible for Alz...