Remodeling of the Intracardiac Ganglia During the Development of Cardiovascular Autonomic Dysfunction in Type 2 Diabetes: Molecular Mechanisms and Therapeutics

• Published in: International journal of molecular sciences Vol. 25; no. 22; p. 12464
• Main Authors: Evans, Anthony J, Li, Yu-Long
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 20.11.2024; MDPI
• Subjects: Analysis; Animals; Autonomic Nervous System - physiopathology; Cardiac arrhythmia; Cardiovascular disease; Cardiovascular diseases; Cardiovascular Diseases - etiology; Care and treatment; Complications and side effects; Development and progression; Diabetes; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - physiopathology; Health aspects; Heart; Heart - innervation; Heart - physiopathology; Heart rate; Humans; Medical law; Mortality; Nervous system; Neural circuitry; Neurons; Neurophysiology; Physiology; Prevention; Review; Risk factors; Type 2 diabetes; Veins & arteries; United States; ventricular arrhythmia; type 2 diabetes mellitus; sudden cardiac death; autonomic dysfunction; intracardiac ganglia

Type 2 diabetes mellitus (T2DM) is one of the most significant health issues worldwide, with associated healthcare costs estimated to surpass USD 1054 billion by 2045. The leading cause of death in T2DM patients is the development of cardiovascular disease (CVD). In the early stages of T2DM, patient...