Bim transfer between Bcl-2-like protein and Hsp70 underlines Bcl-2/Hsp70 crosstalk to regulate apoptosis

• Published in: Biochemical pharmacology Vol. 190; p. 114660
• Main Authors: Zhang, Hong, Guo, Zongwei, Guo, Yafei, Wang, Ziqian, Tang, Yao, Song, Ting, Zhang, Zhichao
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.08.2021
• Subjects: Apoptosis; Bcl-2; Bim; Crosstalk; Hsp70; Bcl-2; Hsp70; Crosstalk; Bim; Apoptosis

[Display omitted] The chaperone heat shock protein 70 (Hsp70) is crucial for avoiding protein misfolding under stress, but it is also upregulated in many kinds of cancers, where its ability to buffer cellular stress prevents apoptosis. Previous research has suggested that Bim, a BH3-only member of t...