Enhancing the Selectivity and Confinement of the Cu(II)‐Mediated Chan‐Lam Coupling for Use in Building Point‐of‐Care Diagnostics

• Published in: ChemElectroChem Vol. 12; no. 8
• Main Authors: Chang, Yu‐Chia, Moeller, Kevin D.
• Format: Journal Article
• Language: English
• Published: Weinheim John Wiley & Sons, Inc 14.04.2025; Wiley-VCH
• Subjects: Acetylene; Aptamer immobilization; Arrays; Chan-Lam Coupling; Chemical reactions; Confinement; Copper; Coupling; Electrodes; Fluorescence; Metabolites; Microelectrode array; Microelectrodes; Nucleophiles; Point-of-Care Diagnostics; Polymers; Reagents; Site-selective reaction

The Cu(II)‐mediated Chan‐Lam coupling reaction offers several benefits for developing point‐of‐care detection devices on microelectrode arrays. However, achieving selectivity on borate ester‐based polymer surfaces has proven difficult due to background reactions. Fluorescence‐based studies were cond...