Fronto-Thalamic Structural Connectivity Associated With Schizotypy, a Psychosis Risk Phenotype, in Nonclinical Subjects

• Published in: Schizophrenia bulletin Vol. 51; no. Supplement_2; pp. S137 - S148
• Main Authors: Nenadić, Igor, Mosebach, Johannes, Schmitt, Simon, Meller, Tina, Stein, Frederike, Brosch, Katharina, Ringwald, Kai, Pfarr, Julia-Katharina, Meinert, Susanne, Lemke, Hannah, Waltemate, Lena, Thiel, Katharina, Opel, Nils, Repple, Jonathan, Grotegerd, Dominik, Steinsträter, Olaf, Sommer, Jens, Hahn, Tim, Jansen, Andreas, Dannlowski, Udo, Krug, Axel, Kircher, Tilo
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 04.03.2025
• Subjects: Adolescent; Adult; Cohort Studies; Connectome; Diffusion Tensor Imaging; Female; Frontal Lobe - diagnostic imaging; Frontal Lobe - pathology; Humans; Male; Nerve Net - diagnostic imaging; Nerve Net - pathology; Phenotype; Psychotic Disorders - pathology; Psychotic Disorders - physiopathology; Schizotypal Personality Disorder - diagnostic imaging; Schizotypal Personality Disorder - pathology; Schizotypal Personality Disorder - physiopathology; Supplement; Thalamus - diagnostic imaging; Thalamus - pathology; White Matter - diagnostic imaging; White Matter - pathology; Young Adult; magnetic resonance imaging (MRI); psychosis proneness; gyrification; cortical folding

Schizotypy is a risk phenotype for the psychosis spectrum and pilot studies suggest a biological continuum underlying this phenotype across health and disease. It is unclear whether this biological continuum might include brain structural associations in networks altered in schizophrenia spectrum di...