Role of Paris PM2.5 components in the pro-inflammatory response induced in airway epithelial cells

• Published in: Toxicology (Amsterdam) Vol. 261; no. 3; pp. 126 - 135
• Main Authors: Baulig, Augustin, Singh, Seema, Marchand, Alexandre, Schins, Roel, Barouki, Robert, Garlatti, Michèle, Marano, Francelyne, Baeza-Squiban, Armelle
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier 10.07.2009
• Subjects: Biological and medical sciences; Chemical and industrial products toxicology. Toxic occupational diseases; Emergency; Medical sciences; Metals and various inorganic compounds; Toxicology; France; Europe; Paris; Ile-de-France; Reactive oxygen species; PM 2.5; EPR; Metals; 16-HBE; 16-HBE14o- cell line; particulate matter with an aerodynamic diameter <2.5 μm; granulocyte macrophage-colony stimulating factor; polycyclic aromatic hydrocarbons; DEP; electron paramagnetic resonance; diesel exhaust particles; GM-CSF; carbon black particles; PAH; Polyaromatic hydrocarbons; Pro-inflammatory cytokines; CB; Oxidative stress; Diesel exhaust particles; Cytokine; Diesel engine; Inflammation; Metal; Polycyclic aromatic compound; Respiratory system; In vitro; Respiratory tract; Fine particle; Epithelial cell; Exhaust gas; PM

Abstract Particulate matter (PM) is suspected to play a role in environmentally-induced pathologies. Due to its complex composition, the contribution of each PM components to PM-induced biological effects remains unclear. Four samples of Paris PM2.5 having different polyaromatic hydrocarbons and met...