Discovery of ErbB/HDAC inhibitors by combining the core pharmacophores of HDAC inhibitor vorinostat and kinase inhibitors vandetanib,BMS-690514,neratinib,and TAK-285

• Published in: Chinese chemical letters Vol. 28; no. 6; pp. 1220 - 1227
• Main Authors: Ding, Chao, Li, Dan, Wang, Yan-Wei, Han, Sai-Sai, Gao, Chun-Mei, Tan, Chun-Yan, Jiang, Yu-Yang
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.06.2017
• Subjects: Anticancer; HDAC; Kinase; Multitarget; Selectivity; Selectivity; Multitarget; Anticancer; Kinase; HDAC

By combining the core pharmacophores of HDAC inhibitor vorinostat and kinase inhibitors vandetanib,BMS-690514,neratinib,and TAK-285 with 1,2,3-triazole as linker,eight novel 6-substituted-4-aminoquinazolin derivatives were synthesized and characterized by -1H NMR,-（13）C NMR,and high resolution mass...