Autoimmune cerebellar ataxia associated with anti-leucine-rich glioma-inactivated protein 1 antibodies: Two pediatric cases
To report two pediatric cases of autoimmune cerebellar ataxia associated with the anti-Leucine-rich glioma-inactivated protein 1 (LGI1)antibodies. The clinical features of the two patients were described retrospectively. The indirect immunofluorescence using transfected cells (cell-based assay, CBA)...
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| Published in | Journal of neuroimmunology Vol. 370; p. 577918 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
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15.09.2022
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| Abstract | To report two pediatric cases of autoimmune cerebellar ataxia associated with the anti-Leucine-rich glioma-inactivated protein 1 (LGI1)antibodies.
The clinical features of the two patients were described retrospectively. The indirect immunofluorescence using transfected cells (cell-based assay, CBA) and the rat cerebellum (tissue-based assay, TBA) with the multi-antigen co-plate biochip mosaic techniques were used to detect the antibodies. Clinical and laboratory characteristics were described.
Two males were included. The onset ages were 2.7y and 4y, respectively. Patient 1 manifested as isolated acute cerebellar ataxia. Patient 2 had extra-cerebellar symptoms, including seizures, encephalopathy, faciobrachial dystonic seizures(FBDs), and significant cerebellar ataxia. The hyponatremia and tumors were not found. Both of them responded well to the immunotherapy.
The autoimmune cerebellar ataxia might be a new phenotype of LGI1-Abs autoimmunity in children. |
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| AbstractList | To report two pediatric cases of autoimmune cerebellar ataxia associated with the anti-Leucine-rich glioma-inactivated protein 1 (LGI1)antibodies.
The clinical features of the two patients were described retrospectively. The indirect immunofluorescence using transfected cells (cell-based assay, CBA) and the rat cerebellum (tissue-based assay, TBA) with the multi-antigen co-plate biochip mosaic techniques were used to detect the antibodies. Clinical and laboratory characteristics were described.
Two males were included. The onset ages were 2.7y and 4y, respectively. Patient 1 manifested as isolated acute cerebellar ataxia. Patient 2 had extra-cerebellar symptoms, including seizures, encephalopathy, faciobrachial dystonic seizures(FBDs), and significant cerebellar ataxia. The hyponatremia and tumors were not found. Both of them responded well to the immunotherapy.
The autoimmune cerebellar ataxia might be a new phenotype of LGI1-Abs autoimmunity in children. To report two pediatric cases of autoimmune cerebellar ataxia associated with the anti-Leucine-rich glioma-inactivated protein 1 (LGI1)antibodies.OBJECTIVESTo report two pediatric cases of autoimmune cerebellar ataxia associated with the anti-Leucine-rich glioma-inactivated protein 1 (LGI1)antibodies.The clinical features of the two patients were described retrospectively. The indirect immunofluorescence using transfected cells (cell-based assay, CBA) and the rat cerebellum (tissue-based assay, TBA) with the multi-antigen co-plate biochip mosaic techniques were used to detect the antibodies. Clinical and laboratory characteristics were described.METHODSThe clinical features of the two patients were described retrospectively. The indirect immunofluorescence using transfected cells (cell-based assay, CBA) and the rat cerebellum (tissue-based assay, TBA) with the multi-antigen co-plate biochip mosaic techniques were used to detect the antibodies. Clinical and laboratory characteristics were described.Two males were included. The onset ages were 2.7y and 4y, respectively. Patient 1 manifested as isolated acute cerebellar ataxia. Patient 2 had extra-cerebellar symptoms, including seizures, encephalopathy, faciobrachial dystonic seizures(FBDs), and significant cerebellar ataxia. The hyponatremia and tumors were not found. Both of them responded well to the immunotherapy.RESULTSTwo males were included. The onset ages were 2.7y and 4y, respectively. Patient 1 manifested as isolated acute cerebellar ataxia. Patient 2 had extra-cerebellar symptoms, including seizures, encephalopathy, faciobrachial dystonic seizures(FBDs), and significant cerebellar ataxia. The hyponatremia and tumors were not found. Both of them responded well to the immunotherapy.The autoimmune cerebellar ataxia might be a new phenotype of LGI1-Abs autoimmunity in children.CONCLUSIONSThe autoimmune cerebellar ataxia might be a new phenotype of LGI1-Abs autoimmunity in children. |
| ArticleNumber | 577918 |
| Author | Ji, Zhou Changhong, Ren Weihua, Zhang Jie, Deng Anna, Zhou Haitao, Ren Xiaotun, Ren Hongzhi, Guan |
| Author_xml | – sequence: 1 givenname: Zhang surname: Weihua fullname: Weihua, Zhang organization: Department of Neurology, Beijing Children's Hospital, Capital Medical University, National Centre for Children's Health, Beijing, China – sequence: 2 givenname: Ren surname: Haitao fullname: Haitao, Ren organization: Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China – sequence: 3 givenname: Deng surname: Jie fullname: Jie, Deng organization: Department of Neurology, Beijing Children's Hospital, Capital Medical University, National Centre for Children's Health, Beijing, China – sequence: 4 givenname: Ren surname: Changhong fullname: Changhong, Ren organization: Department of Neurology, Beijing Children's Hospital, Capital Medical University, National Centre for Children's Health, Beijing, China – sequence: 5 givenname: Zhou surname: Ji fullname: Ji, Zhou organization: Department of Neurology, Beijing Children's Hospital, Capital Medical University, National Centre for Children's Health, Beijing, China – sequence: 6 givenname: Zhou surname: Anna fullname: Anna, Zhou organization: Department of Neurology, Beijing Children's Hospital, Capital Medical University, National Centre for Children's Health, Beijing, China – sequence: 7 givenname: Guan surname: Hongzhi fullname: Hongzhi, Guan email: pumchghz@126.com organization: Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China – sequence: 8 givenname: Ren surname: Xiaotun fullname: Xiaotun, Ren email: renxiaotun@bch.com.cn organization: Department of Neurology, Beijing Children's Hospital, Capital Medical University, National Centre for Children's Health, Beijing, China |
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| Cites_doi | 10.1016/j.neuron.2006.01.033 10.3389/fneur.2020.618109 10.1136/jnnp-2017-315720 10.1186/s12974-015-0358-9 10.1002/ana.25310 10.1007/s12311-019-01048-y 10.1212/NXI.0000000000000371 10.1007/s12311-014-0628-6 10.14802/jmd.20040 10.1016/j.ejpn.2017.08.004 10.1007/s12311-015-0664-x 10.3390/ijms21103701 10.1523/JNEUROSCI.3506-13.2013 10.1016/j.yebeh.2021.108159 10.1093/brain/awq213 10.1111/nan.12132 10.1093/brain/aww012 10.1002/ana.24979 |
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| References | Jarius, Wildemann (bb0035) 2015; 12 Irani, Alexander, Waters (bb0020) 2010; 133 Su, Xie, Zhou, Shen, Hu (bb0105) 2015; 14 Shao, Fan, Luo (bb0095) 2021; 11 López-Chiriboga, Klein, Zekeridou (bb0050) 2018; 84 Schulte, Thumfart, Klocker (bb0090) 2006; 49 Dade, Berzero, Izquierdo (bb0010) 2020; 21 Navarro, Kas, Apartis (bb0065) 2016; 139 Steriade, Day, Lee (bb0100) 2014; 40 Weihua, Haitao, Fang (bb0110) 2019; 18 Lin, Liu, Chen (bb0045) 2021; 122 Ohkawa, Fukata, Yamasaki (bb0070) 2013; 33 Joubert, Gobert, Thomas (bb0040) 2017; 4 Gadoth, Pittock, Dubey (bb0015) 2017; 82 Qiao, Wu, Liu (bb0080) 2021; 17 Schimmel, Fruhwald, Bien (bb0085) 2018; 22 Jarius, Wildemann (bb0025) 2015; 12 Mitoma, Adhikari, Aeschlimann (bb0055) 2016; 15 Binks, Klein, Waters, Pittock, Irani (bb0005) 2018; 89 Jarius, Wildemann (bb0030) 2015; 12 Petit-Pedrol, Sell, Planagumà, Mannara, Radosevic, Haselmann, Ceanga, Sabater, Spatola, Soto, Gasull, Dalmau, Geis (bb0075) 2018 Nov 1; 141 Mitoma, Manto, Hadjivassiliou (bb0060) 2021; 14 Schulte (10.1016/j.jneuroim.2022.577918_bb0090) 2006; 49 Steriade (10.1016/j.jneuroim.2022.577918_bb0100) 2014; 40 Weihua (10.1016/j.jneuroim.2022.577918_bb0110) 2019; 18 Qiao (10.1016/j.jneuroim.2022.577918_bb0080) 2021; 17 Joubert (10.1016/j.jneuroim.2022.577918_bb0040) 2017; 4 Lin (10.1016/j.jneuroim.2022.577918_bb0045) 2021; 122 Navarro (10.1016/j.jneuroim.2022.577918_bb0065) 2016; 139 Jarius (10.1016/j.jneuroim.2022.577918_bb0030) 2015; 12 Jarius (10.1016/j.jneuroim.2022.577918_bb0035) 2015; 12 Binks (10.1016/j.jneuroim.2022.577918_bb0005) 2018; 89 Shao (10.1016/j.jneuroim.2022.577918_bb0095) 2021; 11 Gadoth (10.1016/j.jneuroim.2022.577918_bb0015) 2017; 82 Su (10.1016/j.jneuroim.2022.577918_bb0105) 2015; 14 Dade (10.1016/j.jneuroim.2022.577918_bb0010) 2020; 21 Petit-Pedrol (10.1016/j.jneuroim.2022.577918_bb0075) 2018; 141 Schimmel (10.1016/j.jneuroim.2022.577918_bb0085) 2018; 22 Irani (10.1016/j.jneuroim.2022.577918_bb0020) 2010; 133 López-Chiriboga (10.1016/j.jneuroim.2022.577918_bb0050) 2018; 84 Ohkawa (10.1016/j.jneuroim.2022.577918_bb0070) 2013; 33 Mitoma (10.1016/j.jneuroim.2022.577918_bb0060) 2021; 14 Jarius (10.1016/j.jneuroim.2022.577918_bb0025) 2015; 12 Mitoma (10.1016/j.jneuroim.2022.577918_bb0055) 2016; 15 |
| References_xml | – volume: 89 start-page: 526 year: 2018 end-page: 534 ident: bb0005 article-title: LGI1, CASPR2 and related antibodies: a molecular evolution of the phenotypes publication-title: J. Neurol. Neurosurg. Psychiatry – volume: 11 year: 2021 ident: bb0095 article-title: Brain magnetic resonance imaging characteristics of anti-leucine-rich glioma-inactivated 1 encephalitis and their clinical relevance: a single-center study in China publication-title: Front. Neurol. – volume: 133 start-page: 2734 year: 2010 end-page: 2748 ident: bb0020 article-title: Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan’s syndrome and acquired neuromyotonia publication-title: Brain – volume: 82 start-page: 79 year: 2017 end-page: 92 ident: bb0015 article-title: Expanded phenotypes and outcomes among 256 LGI1/CASPR2-IgG-positive patients publication-title: Ann. Neurol. – volume: 49 start-page: 697 year: 2006 end-page: 706 ident: bb0090 article-title: The epilepsy-linked Lgi1 protein assembles into presynaptic Kv1 channels and inhibits inactivation by Kvbeta1 publication-title: Neuron. – volume: 17 start-page: 203 year: 2021 end-page: 212 ident: bb0080 article-title: Clinical features and long-term outcomes of anti-leucine-rich glioma-inactivated 1 encephalitis publication-title: Multi Center Study. – volume: 18 start-page: 1137 year: 2019 end-page: 1142 ident: bb0110 article-title: Neurochondrin antibody serum positivity in three cases of autoimmune cerebellar Ataxia publication-title: Cerebellum. – volume: 14 start-page: 10 year: 2021 end-page: 28 ident: bb0060 article-title: Immune-mediated cerebellar ataxias: clinical diagnosis and treatment based on immunological and physiological mechanisms publication-title: J. Mov. Disord. – volume: 22 start-page: 190 year: 2018 end-page: 193 ident: bb0085 article-title: Limbic encephalitis with LGI1 antibodies in a 14-year-old boy publication-title: Eur. J. Paediatr. Neurol. – volume: 33 start-page: 18161 year: 2013 end-page: 18174 ident: bb0070 article-title: Autoantibodies to epilepsy-related LGI1 in limbic encephalitis neutralize LGI1-ADAM22 interaction and reduce synaptic AMPA receptors publication-title: J. Neurosci. – volume: 15 start-page: 213 year: 2016 end-page: 232 ident: bb0055 article-title: Consensus paper: neuroimmune mechanisms of cerebellar ataxias publication-title: Cerebellum. – volume: 84 start-page: 473 year: 2018 end-page: 480 ident: bb0050 article-title: LGI1 and CASPR2 neurological autoimmunity in children publication-title: Ann. Neurol. – volume: 4 year: 2017 ident: bb0040 article-title: Autoimmune episodic ataxia in patients with anti-CASPR2 antibody-associated encephalitis publication-title: Neurol. Neuroimmunol. Neuroinflamm. – volume: 40 start-page: 645 year: 2014 end-page: 649 ident: bb0100 article-title: LGI1 autoantibodies associated with cerebellar degeneration publication-title: Neuropathol. Appl. Neurobiol. – volume: 12 year: 2015 ident: bb0030 article-title: ‘Medusa head ataxia’: the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 2: anti-PKC-gamma, anti-GluR-delta2, anti-ca/ARHGAP26 and anti-VGCC publication-title: J. Neuroinflammation – volume: 12 year: 2015 ident: bb0025 article-title: ‘Medusa head ataxia’: the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 1: anti-mGluR1, anti-Homer-3, anti-Sj/ITPR1 and anti-CARP VIII publication-title: J. Neuroinflammation – volume: 14 start-page: 12 year: 2015 end-page: 14 ident: bb0105 article-title: LGI1 is involved in the development of mouse brain publication-title: Cerebellum – volume: 141 start-page: 3144 year: 2018 Nov 1 end-page: 3159 ident: bb0075 article-title: LGI1 antibodies alter Kv1.1 and AMPA receptors changing synaptic excitability, plasticity and memory publication-title: Brain. – volume: 21 start-page: 3701 year: 2020 ident: bb0010 article-title: Neurological syndromes associated with anti-GAD antibodies publication-title: Int. J. Mol. Sci. – volume: 122 year: 2021 ident: bb0045 article-title: Long-term seizure outcomes in patients with anti-leucine-rich glioma-inactivated 1 encephalitis publication-title: Epilepsy Behav. – volume: 139 start-page: 1079 year: 2016 end-page: 1093 ident: bb0065 article-title: Motor cortex and hippocampus are the two main cortical targets in LGI1-antibody encephalitis publication-title: Brain. – volume: 12 year: 2015 ident: bb0035 article-title: ‘Medusa head ataxia’: the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 3: anti-Yo/CDR2, anti-Nb/AP3B2, PCA-2, anti-Tr/DNER, other antibodies, diagnostic pitfalls, summary and outlook publication-title: J. Neuroinflammation – volume: 49 start-page: 697 issue: 5 year: 2006 ident: 10.1016/j.jneuroim.2022.577918_bb0090 article-title: The epilepsy-linked Lgi1 protein assembles into presynaptic Kv1 channels and inhibits inactivation by Kvbeta1 publication-title: Neuron. doi: 10.1016/j.neuron.2006.01.033 – volume: 11 year: 2021 ident: 10.1016/j.jneuroim.2022.577918_bb0095 article-title: Brain magnetic resonance imaging characteristics of anti-leucine-rich glioma-inactivated 1 encephalitis and their clinical relevance: a single-center study in China publication-title: Front. Neurol. doi: 10.3389/fneur.2020.618109 – volume: 89 start-page: 526 issue: 5 year: 2018 ident: 10.1016/j.jneuroim.2022.577918_bb0005 article-title: LGI1, CASPR2 and related antibodies: a molecular evolution of the phenotypes publication-title: J. Neurol. Neurosurg. Psychiatry doi: 10.1136/jnnp-2017-315720 – volume: 12 issue: 1 year: 2015 ident: 10.1016/j.jneuroim.2022.577918_bb0035 article-title: ‘Medusa head ataxia’: the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 3: anti-Yo/CDR2, anti-Nb/AP3B2, PCA-2, anti-Tr/DNER, other antibodies, diagnostic pitfalls, summary and outlook publication-title: J. Neuroinflammation doi: 10.1186/s12974-015-0358-9 – volume: 84 start-page: 473 issue: 3 year: 2018 ident: 10.1016/j.jneuroim.2022.577918_bb0050 article-title: LGI1 and CASPR2 neurological autoimmunity in children publication-title: Ann. Neurol. doi: 10.1002/ana.25310 – volume: 18 start-page: 1137 issue: 6 year: 2019 ident: 10.1016/j.jneuroim.2022.577918_bb0110 article-title: Neurochondrin antibody serum positivity in three cases of autoimmune cerebellar Ataxia publication-title: Cerebellum. doi: 10.1007/s12311-019-01048-y – volume: 4 issue: 4 year: 2017 ident: 10.1016/j.jneuroim.2022.577918_bb0040 article-title: Autoimmune episodic ataxia in patients with anti-CASPR2 antibody-associated encephalitis publication-title: Neurol. Neuroimmunol. Neuroinflamm. doi: 10.1212/NXI.0000000000000371 – volume: 14 start-page: 12 issue: 1 year: 2015 ident: 10.1016/j.jneuroim.2022.577918_bb0105 article-title: LGI1 is involved in the development of mouse brain publication-title: Cerebellum doi: 10.1007/s12311-014-0628-6 – volume: 17 start-page: 203 year: 2021 ident: 10.1016/j.jneuroim.2022.577918_bb0080 article-title: Clinical features and long-term outcomes of anti-leucine-rich glioma-inactivated 1 encephalitis publication-title: Multi Center Study. – volume: 14 start-page: 10 issue: 1 year: 2021 ident: 10.1016/j.jneuroim.2022.577918_bb0060 article-title: Immune-mediated cerebellar ataxias: clinical diagnosis and treatment based on immunological and physiological mechanisms publication-title: J. Mov. Disord. doi: 10.14802/jmd.20040 – volume: 22 start-page: 190 issue: 1 year: 2018 ident: 10.1016/j.jneuroim.2022.577918_bb0085 article-title: Limbic encephalitis with LGI1 antibodies in a 14-year-old boy publication-title: Eur. J. Paediatr. Neurol. doi: 10.1016/j.ejpn.2017.08.004 – volume: 15 start-page: 213 issue: 2 year: 2016 ident: 10.1016/j.jneuroim.2022.577918_bb0055 article-title: Consensus paper: neuroimmune mechanisms of cerebellar ataxias publication-title: Cerebellum. doi: 10.1007/s12311-015-0664-x – volume: 21 start-page: 3701 issue: 10 year: 2020 ident: 10.1016/j.jneuroim.2022.577918_bb0010 article-title: Neurological syndromes associated with anti-GAD antibodies publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms21103701 – volume: 33 start-page: 18161 issue: 46 year: 2013 ident: 10.1016/j.jneuroim.2022.577918_bb0070 article-title: Autoantibodies to epilepsy-related LGI1 in limbic encephalitis neutralize LGI1-ADAM22 interaction and reduce synaptic AMPA receptors publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.3506-13.2013 – volume: 12 issue: 1 year: 2015 ident: 10.1016/j.jneuroim.2022.577918_bb0030 article-title: ‘Medusa head ataxia’: the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 2: anti-PKC-gamma, anti-GluR-delta2, anti-ca/ARHGAP26 and anti-VGCC publication-title: J. Neuroinflammation doi: 10.1186/s12974-015-0358-9 – volume: 122 year: 2021 ident: 10.1016/j.jneuroim.2022.577918_bb0045 article-title: Long-term seizure outcomes in patients with anti-leucine-rich glioma-inactivated 1 encephalitis publication-title: Epilepsy Behav. doi: 10.1016/j.yebeh.2021.108159 – volume: 12 issue: 1 year: 2015 ident: 10.1016/j.jneuroim.2022.577918_bb0025 article-title: ‘Medusa head ataxia’: the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 1: anti-mGluR1, anti-Homer-3, anti-Sj/ITPR1 and anti-CARP VIII publication-title: J. Neuroinflammation doi: 10.1186/s12974-015-0358-9 – volume: 133 start-page: 2734 issue: 9 year: 2010 ident: 10.1016/j.jneuroim.2022.577918_bb0020 article-title: Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan’s syndrome and acquired neuromyotonia publication-title: Brain doi: 10.1093/brain/awq213 – volume: 40 start-page: 645 issue: 5 year: 2014 ident: 10.1016/j.jneuroim.2022.577918_bb0100 article-title: LGI1 autoantibodies associated with cerebellar degeneration publication-title: Neuropathol. Appl. Neurobiol. doi: 10.1111/nan.12132 – volume: 139 start-page: 1079 issue: 4 year: 2016 ident: 10.1016/j.jneuroim.2022.577918_bb0065 article-title: Motor cortex and hippocampus are the two main cortical targets in LGI1-antibody encephalitis publication-title: Brain. doi: 10.1093/brain/aww012 – volume: 82 start-page: 79 issue: 1 year: 2017 ident: 10.1016/j.jneuroim.2022.577918_bb0015 article-title: Expanded phenotypes and outcomes among 256 LGI1/CASPR2-IgG-positive patients publication-title: Ann. Neurol. doi: 10.1002/ana.24979 – volume: 141 start-page: 3144 issue: 11 year: 2018 ident: 10.1016/j.jneuroim.2022.577918_bb0075 article-title: LGI1 antibodies alter Kv1.1 and AMPA receptors changing synaptic excitability, plasticity and memory publication-title: Brain. |
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| Snippet | To report two pediatric cases of autoimmune cerebellar ataxia associated with the anti-Leucine-rich glioma-inactivated protein 1 (LGI1)antibodies.
The clinical... To report two pediatric cases of autoimmune cerebellar ataxia associated with the anti-Leucine-rich glioma-inactivated protein 1 (LGI1)antibodies.OBJECTIVESTo... |
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| Title | Autoimmune cerebellar ataxia associated with anti-leucine-rich glioma-inactivated protein 1 antibodies: Two pediatric cases |
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