Discovery of biphenyls bearing thiobarbiturate fragment by structure-based strategy as Mycobacterium tuberculosis protein tyrosine phosphatase B inhibitors

• Published in: Bioorganic & medicinal chemistry Vol. 73; pp. 117006 - 117018
• Main Authors: Cheng, Shihao, Wang, Qinglin, Chen, Xi, Chen, Jiahao, Wang, Bin, Chen, Dongni, Shen, Dong, Tian, Jinying, Ye, Fei, Lu, Yu, Huang, Haihong, Lu, Yongjun, Zhang, Dongfeng
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 01.11.2022; Elsevier
• Subjects: Biochemistry & Molecular Biology; Biphenyls with thiobarbiturate fragment; Chemistry; Chemistry, Medicinal; Chemistry, Organic; Life Sciences & Biomedicine; MptpB; Pharmacology & Pharmacy; Physical Sciences; Science & Technology; Structure-based molecular design strategy; Tuberculosis; Biphenyls with thiobarbiturate fragment; MptpB; Structure-based molecular design strategy; Tuberculosis; IDENTIFICATION

[Display omitted] Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) is an important virulence factor that blocks the host immune response and facilitates M. tuberculosis growth in host cells. MptpB inhibitors are potential components of tuberculosis combination treatment. Herein, we...