Changes in forebrain function from waking to REM sleep in depression: preliminary analyses [of 18F]FDG PET studies

• Published in: Psychiatry research Vol. 91; no. 2; pp. 59 - 78
• Main Authors: Nofzinger, Eric A., Nichols, Thomas E., Meltzer, Carolyn C., Price, Julie, Steppe, Doris A., Miewald, Jean M., Kupfer, David J., Moore, Robert Y.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 31.08.1999
• Subjects: Adult; Blood Glucose - metabolism; Cerebral glucose metabolism; Depressive Disorder, Major - psychology; Electroencephalography; Female; Fluorodeoxyglucose F18 - pharmacokinetics; Functional Laterality - physiology; Humans; Image Processing, Computer-Assisted; Limbic system; Major depressive disorder; Male; Middle Aged; Positron emission tomography; Prosencephalon - blood supply; Prosencephalon - diagnostic imaging; Prosencephalon - metabolism; Radiopharmaceuticals - pharmacokinetics; REM sleep; Sleep, REM - physiology; Time Factors; Tomography, Emission-Computed; Wakefulness - physiology; Limbic system; Positron emission tomography; Major depressive disorder; Cerebral glucose metabolism; REM sleep

Based on recent functional brain imaging studies of healthy human REM sleep, we hypothesized that alterations in REM sleep in mood disorder patients reflect a functional dysregulation within limbic and paralimbic forebrain structures during that sleep state. Six unipolar depressed subjects and eight...