Pulmonary adenocarcinomas associated with rheumatoid nodules: a case report and review of the literature

Necrobiotic lung nodules and primary lung carcinoma both occur with some frequency in patients with rheumatoid arthritis; however, few reports exist of a primary lung carcinoma occurring within a rheumatoid nodule. We report a case of a 62-year-old woman with multiple pulmonary nodules discovered in...

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Published inArchives of pathology & laboratory medicine (1976) Vol. 129; no. 1; pp. 104 - 106
Main Authors Baruch, Amy C, Steinbronn, Karen, Sobonya, Richard
Format Journal Article
LanguageEnglish
Published United States College of American Pathologists 01.01.2005
Subjects
Adenocarcinoma - etiology
Female
Humans
Literature reviews
Lung Diseases - complications
Lung Neoplasms - etiology
Middle Aged
Rheumatoid Nodule - complications
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Summary:Necrobiotic lung nodules and primary lung carcinoma both occur with some frequency in patients with rheumatoid arthritis; however, few reports exist of a primary lung carcinoma occurring within a rheumatoid nodule. We report a case of a 62-year-old woman with multiple pulmonary nodules discovered incidentally by computed tomography. Although 2 of the lesions were composed solely of necrotizing granulomas, 2 additional lesions contained malignant glands at the periphery of necrobiotic nodules. Immunohistochemical staining supported the diagnosis of both tumors as primary lung carcinomas. Our literature search revealed only 2 other reported cases of adenocarcinoma occurring in association with a rheumatoid nodule; these cases, as well as the association between rheumatoid disease and malignancy, are briefly reviewed.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
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ObjectType-Report-1
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ISSN:0003-9985
1543-2165
DOI:10.5858/2005-129-104-PAAWRN