Effect of anemia and erythrocyte indices on hemoglobin A1c levels among pregnant women
•Mild and moderate anemia should not be the primary concern when using HbA1c to monitor blood glucose in pregnancy.•Mean corpuscular volume and mean corpuscular hemoglobin in anemic pregnant women are not consistent with the hypochromic microcytes characteristics in IDA.•Mean corpuscular hemoglobin,...
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Published in | Clinica chimica acta Vol. 534; pp. 1 - 5 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
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Elsevier B.V
01.09.2022
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Abstract | •Mild and moderate anemia should not be the primary concern when using HbA1c to monitor blood glucose in pregnancy.•Mean corpuscular volume and mean corpuscular hemoglobin in anemic pregnant women are not consistent with the hypochromic microcytes characteristics in IDA.•Mean corpuscular hemoglobin, rather than anemia, may play a fundamental role in influencing HbA1c.
Anemia is a common disorder among pregnant women; however, the effect of anemia on hemoglobin A1c (HbA1c) levels has not been adequately explored. We aim to examine the influence of anemia on the HbA1c concentration and investigate the relationship between erythrocyte indices and HbA1c levels during pregnancy.
We performed a retrospective analysis of 1369 pregnant Chinese women. The clinical and analytical data were collected. Independent t-test and Analysis of Variance were used for comparative studies, and multiple linear regression analysis was used to identify the association between erythrocyte indices and HbA1c.
The differences in HbA1c between non-anemia and mild anemia were negligible, and the differences in HbA1c between non-anemia and moderate anemia were well within the allowable variability for clinical practice (≥0.5% absolute changes). Mean corpuscular hemoglobin (MCH) correlated with HbA1c significantly, independent of pregnancy, trimester, and anemia. The distinction of HbA1c levels between grades of Hb became no significant (P = 0.955), while differences between trimesters persisted after adjusting for MCH.
Mild and moderate anemia should not be the primary concern when using HbA1c to monitor blood glucose in pregnancy. MCH showed negative correlations with HbA1c independently, suggesting a previously unknown mechanism affecting HbA1c levels. |
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AbstractList | BACKGROUNDAnemia is a common disorder among pregnant women; however, the effect of anemia on hemoglobin A1c (HbA1c) levels has not been adequately explored. We aim to examine the influence of anemia on the HbA1c concentration and investigate the relationship between erythrocyte indices and HbA1c levels during pregnancy. METHODSWe performed a retrospective analysis of 1369 pregnant Chinese women. The clinical and analytical data were collected. Independent t-test and Analysis of Variance were used for comparative studies, and multiple linear regression analysis was used to identify the association between erythrocyte indices and HbA1c. RESULTSThe differences in HbA1c between non-anemia and mild anemia were negligible, and the differences in HbA1c between non-anemia and moderate anemia were well within the allowable variability for clinical practice (≥0.5% absolute changes). Mean corpuscular hemoglobin (MCH) correlated with HbA1c significantly, independent of pregnancy, trimester, and anemia. The distinction of HbA1c levels between grades of Hb became no significant (P = 0.955), while differences between trimesters persisted after adjusting for MCH. CONCLUSIONMild and moderate anemia should not be the primary concern when using HbA1c to monitor blood glucose in pregnancy. MCH showed negative correlations with HbA1c independently, suggesting a previously unknown mechanism affecting HbA1c levels. •Mild and moderate anemia should not be the primary concern when using HbA1c to monitor blood glucose in pregnancy.•Mean corpuscular volume and mean corpuscular hemoglobin in anemic pregnant women are not consistent with the hypochromic microcytes characteristics in IDA.•Mean corpuscular hemoglobin, rather than anemia, may play a fundamental role in influencing HbA1c. Anemia is a common disorder among pregnant women; however, the effect of anemia on hemoglobin A1c (HbA1c) levels has not been adequately explored. We aim to examine the influence of anemia on the HbA1c concentration and investigate the relationship between erythrocyte indices and HbA1c levels during pregnancy. We performed a retrospective analysis of 1369 pregnant Chinese women. The clinical and analytical data were collected. Independent t-test and Analysis of Variance were used for comparative studies, and multiple linear regression analysis was used to identify the association between erythrocyte indices and HbA1c. The differences in HbA1c between non-anemia and mild anemia were negligible, and the differences in HbA1c between non-anemia and moderate anemia were well within the allowable variability for clinical practice (≥0.5% absolute changes). Mean corpuscular hemoglobin (MCH) correlated with HbA1c significantly, independent of pregnancy, trimester, and anemia. The distinction of HbA1c levels between grades of Hb became no significant (P = 0.955), while differences between trimesters persisted after adjusting for MCH. Mild and moderate anemia should not be the primary concern when using HbA1c to monitor blood glucose in pregnancy. MCH showed negative correlations with HbA1c independently, suggesting a previously unknown mechanism affecting HbA1c levels. |
Author | Chen, Fei Tian, Huai-Liang Guo, Zong-Hui Zhang, Xiao-Qian Zhang, Deng-Han Su, Wen-Wen Wang, Kun Wang, Zhi-Min |
Author_xml | – sequence: 1 givenname: Zong-Hui surname: Guo fullname: Guo, Zong-Hui email: guozonghui0113@163.com – sequence: 2 givenname: Huai-Liang surname: Tian fullname: Tian, Huai-Liang – sequence: 3 givenname: Xiao-Qian surname: Zhang fullname: Zhang, Xiao-Qian – sequence: 4 givenname: Deng-Han surname: Zhang fullname: Zhang, Deng-Han – sequence: 5 givenname: Zhi-Min surname: Wang fullname: Wang, Zhi-Min – sequence: 6 givenname: Kun surname: Wang fullname: Wang, Kun – sequence: 7 givenname: Wen-Wen surname: Su fullname: Su, Wen-Wen – sequence: 8 givenname: Fei surname: Chen fullname: Chen, Fei |
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Snippet | •Mild and moderate anemia should not be the primary concern when using HbA1c to monitor blood glucose in pregnancy.•Mean corpuscular volume and mean... BACKGROUNDAnemia is a common disorder among pregnant women; however, the effect of anemia on hemoglobin A1c (HbA1c) levels has not been adequately explored. We... |
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SubjectTerms | Erythrocyte indices Hemoglobin A1c Pregnancy Anemia |
Title | Effect of anemia and erythrocyte indices on hemoglobin A1c levels among pregnant women |
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