Mastocytic Enterocolitis: Increased Mucosal Mast Cells in Chronic Intractable Diarrhea

• Published in: Archives of pathology & laboratory medicine (1976) Vol. 130; no. 3; pp. 362 - 367
• Main Authors: Jakate, Shriram, Demeo, Mark, John, Rohan, Tobin, Mary, Keshavarzian, Ali
• Format: Journal Article
• Language: English
• Published: United States College of American Pathologists 01.03.2006
• Subjects: Abdomen; Adult; Aged; Biopsy; Celiac disease; Cell Count; Cetirizine - therapeutic use; Chronic Disease; Colon; Colon - enzymology; Colon - pathology; Diarrhea; Diarrhea - drug therapy; Diarrhea - etiology; Diarrhea - pathology; Drug Therapy, Combination; Duodenum - enzymology; Duodenum - pathology; Endoscopy; Enterocolitis - drug therapy; Enterocolitis - etiology; Enterocolitis - pathology; Fecal incontinence; Female; Histamine H1 Antagonists, Non-Sedating - therapeutic use; Humans; Inflammatory bowel disease; Intestinal Mucosa - drug effects; Intestinal Mucosa - pathology; Irritable bowel syndrome; Male; Mast Cells - drug effects; Mast Cells - enzymology; Mast Cells - pathology; Mastocytosis, Systemic - complications; Mastocytosis, Systemic - drug therapy; Mastocytosis, Systemic - pathology; Middle Aged; Polyps; Ranitidine - therapeutic use; Serine Endopeptidases - metabolism; Small intestine; Treatment Outcome; Tryptases

Context.—In some adult patients with chronic intractable diarrhea, the diagnosis remains elusive even after detailed evaluations, and colonic or duodenal biopsy specimens may appear unremarkable on routine hematoxylin-eosin staining. Objectives.—To assess the concentration of mast cells in colonic o...