High prevalence of xylazine among fentanyl screen-positive urines from hospitalized patients, Philadelphia, 2021

• Published in: Clinica chimica acta Vol. 521; pp. 151 - 154
• Main Authors: Korn, Warren R., Stone, Matthew D., Haviland, Kaddie L., Toohey, Joanne M., Stickle, Douglas F.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.10.2021
• Subjects: Adulterants; DOAU; Fentanyl; Mass spectrometry; Opiates; Xylazine; Xylazine; Fentanyl; Opiates; Adulterants; Mass spectrometry; DOAU
• ISSN: 0009-8981; 1873-3492; 1873-3492
• DOI: 10.1016/j.cca.2021.07.010

•An LC-MS/MS assasy was developed to detect xylazine in urine.•Lower limit of detection was 10 ng/mL.•We tested for xylazine in fentanyl screen-positive urines from hospitalized subjects.•78% of fentanyl screen-positive urines were positive for xylazine by LC-MS/MS. Xylazine is an α-2 adrenoreceptor...