Target controlled alternative hybridization chain reaction for fluorescent detection of dual mycotoxins
A target controlled alternative hybridization chain reaction (HCR) was developed for fluorescent detection of multiple mycotoxin. Ochratoxin A (OTA) and aflatoxin B1 (AFB1) can bind with their specific aptamer on the gold nanoparticles and cause the releasing of the short DNA sequences. The short DN...
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| Published in | Analytica chimica acta Vol. 1237; p. 340595 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
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Elsevier B.V
02.01.2023
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| Subjects | |
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| Abstract | A target controlled alternative hybridization chain reaction (HCR) was developed for fluorescent detection of multiple mycotoxin. Ochratoxin A (OTA) and aflatoxin B1 (AFB1) can bind with their specific aptamer on the gold nanoparticles and cause the releasing of the short DNA sequences. The short DNA sequences can trigger different reaction route of HCR and thus produce two kinds of side-chain sequences. The side-chain sequences can cause the opening of the DNA tweezers and result the recovery of fluorescent signals. Good linear relationships were obtained in the range of 0.06–2 ng/mL (R2 = 0.994) for OTA and 0.005–1 ng/mL (R2 = 0.992) for AFB1 with limit of detection of 0.02 ng/mL for OTA and 0.002 ng/mL for AFB1. Importantly, it showed great sensitivity and excellent selectivity in practical food sample analysis for simultaneous detection of OTA and AFB1.
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•An alternative hybridization chain reaction was developed for dual mycotoxins detection.•The hybridization chain reaction route can be controlled by the target.•This strategy shows promising potentials for simultaneous detection of OTA and AFB1. |
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| AbstractList | A target controlled alternative hybridization chain reaction (HCR) was developed for fluorescent detection of multiple mycotoxin. Ochratoxin A (OTA) and aflatoxin B1 (AFB1) can bind with their specific aptamer on the gold nanoparticles and cause the releasing of the short DNA sequences. The short DNA sequences can trigger different reaction route of HCR and thus produce two kinds of side-chain sequences. The side-chain sequences can cause the opening of the DNA tweezers and result the recovery of fluorescent signals. Good linear relationships were obtained in the range of 0.06-2 ng/mL (R2 = 0.994) for OTA and 0.005-1 ng/mL (R2 = 0.992) for AFB1 with limit of detection of 0.02 ng/mL for OTA and 0.002 ng/mL for AFB1. Importantly, it showed great sensitivity and excellent selectivity in practical food sample analysis for simultaneous detection of OTA and AFB1.A target controlled alternative hybridization chain reaction (HCR) was developed for fluorescent detection of multiple mycotoxin. Ochratoxin A (OTA) and aflatoxin B1 (AFB1) can bind with their specific aptamer on the gold nanoparticles and cause the releasing of the short DNA sequences. The short DNA sequences can trigger different reaction route of HCR and thus produce two kinds of side-chain sequences. The side-chain sequences can cause the opening of the DNA tweezers and result the recovery of fluorescent signals. Good linear relationships were obtained in the range of 0.06-2 ng/mL (R2 = 0.994) for OTA and 0.005-1 ng/mL (R2 = 0.992) for AFB1 with limit of detection of 0.02 ng/mL for OTA and 0.002 ng/mL for AFB1. Importantly, it showed great sensitivity and excellent selectivity in practical food sample analysis for simultaneous detection of OTA and AFB1. A target controlled alternative hybridization chain reaction (HCR) was developed for fluorescent detection of multiple mycotoxin. Ochratoxin A (OTA) and aflatoxin B1 (AFB1) can bind with their specific aptamer on the gold nanoparticles and cause the releasing of the short DNA sequences. The short DNA sequences can trigger different reaction route of HCR and thus produce two kinds of side-chain sequences. The side-chain sequences can cause the opening of the DNA tweezers and result the recovery of fluorescent signals. Good linear relationships were obtained in the range of 0.06–2 ng/mL (R2 = 0.994) for OTA and 0.005–1 ng/mL (R2 = 0.992) for AFB1 with limit of detection of 0.02 ng/mL for OTA and 0.002 ng/mL for AFB1. Importantly, it showed great sensitivity and excellent selectivity in practical food sample analysis for simultaneous detection of OTA and AFB1. [Display omitted] •An alternative hybridization chain reaction was developed for dual mycotoxins detection.•The hybridization chain reaction route can be controlled by the target.•This strategy shows promising potentials for simultaneous detection of OTA and AFB1. |
| ArticleNumber | 340595 |
| Author | Yang, Lizhu Lin, Yiyan Yang, Yun Yun, Wen Ma, Qin Yang, Wenming Zhang, Mingming |
| Author_xml | – sequence: 1 givenname: Qin surname: Ma fullname: Ma, Qin organization: Division of Gastrointestinal Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, China – sequence: 2 givenname: Yiyan surname: Lin fullname: Lin, Yiyan organization: Chongqing Key Laboratory of Catalysis and New Environmental Materials, College of Environment and Resources, Chongqing Technology and Business University, Chongqing, 400067, China – sequence: 3 givenname: Yun orcidid: 0000-0002-0335-5646 surname: Yang fullname: Yang, Yun organization: Colorectal Cancer Center, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, China – sequence: 4 givenname: Wenming surname: Yang fullname: Yang, Wenming organization: Division of Gastrointestinal Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, China – sequence: 5 givenname: Wen surname: Yun fullname: Yun, Wen organization: Chongqing Key Laboratory of Catalysis and New Environmental Materials, College of Environment and Resources, Chongqing Technology and Business University, Chongqing, 400067, China – sequence: 6 givenname: Mingming surname: Zhang fullname: Zhang, Mingming email: mmzhangmd@163.com organization: Division of Gastrointestinal Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, China – sequence: 7 givenname: Lizhu surname: Yang fullname: Yang, Lizhu email: yanglz3000@aliyun.com organization: School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China |
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| Keywords | Aflatoxin B1 Hybridization chain reaction DNA tweezer Ochratoxin A Mycotoxin |
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| SubjectTerms | Aflatoxin B1 DNA tweezer Hybridization chain reaction Mycotoxin Ochratoxin A |
| Title | Target controlled alternative hybridization chain reaction for fluorescent detection of dual mycotoxins |
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