Metabolomics analysis II. Preparation of biological samples prior to detection

After discussing the significance of preliminary operations, such as selection or storage of biological samples, we critically review the other steps of the analytical process prior to metabolite detection. First comes interruption of metabolism or quenching, which is of crucial importance in the an...

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Published inTrAC, Trends in analytical chemistry (Regular ed.) Vol. 29; no. 2; pp. 120 - 127
Main Authors Álvarez-Sánchez, B., Priego-Capote, F., Castro, M.D. Luque de
Format Journal Article
LanguageEnglish
Published Kidlington Elsevier B.V 01.02.2010
Elsevier
Subjects
Analytical chemistry
Chemistry
Clean up
Derivatization
Exact sciences and technology
Extraction
Fractionation
Metabolite
Metabolomics
Preconcentration
Quenching
Sample preparation
Separation
Clean up
Metabolomics
Fractionation
Sample preparation
Separation
Metabolite
Preconcentration
Extraction
Derivatization
Quenching
Cell culture
Chemical analysis
Sample
Selection
Review
Metabolism
Chemical enrichment
Biological compound
Target
Storage
Sample cell
Analytical method
Detection
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Abstract After discussing the significance of preliminary operations, such as selection or storage of biological samples, we critically review the other steps of the analytical process prior to metabolite detection. First comes interruption of metabolism or quenching, which is of crucial importance in the analysis of biological samples. Then, we consider quantitative extraction of metabolites (selective or total for targeted or global metabolomics analysis, respectively) as a function of sample characteristics: solid or liquid samples and cell culture. Finally, we comment on additional steps, such as preconcentration of metabolites, clean up of extracts and fractionation for metabolite separation, and discuss their inclusion in analytical methods.
AbstractList After discussing the significance of preliminary operations, such as selection or storage of biological samples, we critically review the other steps of the analytical process prior to metabolite detection. First comes interruption of metabolism or quenching, which is of crucial importance in the analysis of biological samples. Then, we consider quantitative extraction of metabolites (selective or total for targeted or global metabolomics analysis, respectively) as a function of sample characteristics: solid or liquid samples and cell culture. Finally, we comment on additional steps, such as preconcentration of metabolites, clean up of extracts and fractionation for metabolite separation, and discuss their inclusion in analytical methods.
Author Castro, M.D. Luque de
Álvarez-Sánchez, B.
Priego-Capote, F.
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  fullname: Priego-Capote, F.
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  givenname: M.D. Luque de
  surname: Castro
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Issue 2
Keywords Clean up
Metabolomics
Fractionation
Sample preparation
Separation
Metabolite
Preconcentration
Extraction
Derivatization
Quenching
Cell culture
Chemical analysis
Sample
Selection
Review
Metabolism
Chemical enrichment
Biological compound
Target
Storage
Sample cell
Analytical method
Detection
Language English
License CC BY 4.0
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Snippet After discussing the significance of preliminary operations, such as selection or storage of biological samples, we critically review the other steps of the...
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SubjectTerms Analytical chemistry
Chemistry
Clean up
Derivatization
Exact sciences and technology
Extraction
Fractionation
Metabolite
Metabolomics
Preconcentration
Quenching
Sample preparation
Separation
Title Metabolomics analysis II. Preparation of biological samples prior to detection
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