Distinct sex-dependent behavioral responses induced by two positive allosteric modulators of alpha 5 subunit-containing GABAA receptors

• Published in: Behavioural brain research Vol. 428; p. 113832
• Main Authors: Souza, Adriana Jesus, Cortez, Isadora L., Silva, Nicole R., Pedrazzi, João Francisco C., Domingos, Luana B., Braga, Matheus Silva, Santos-Silva, Thamyris, Del-Bel, Elaine A., Resstel, Leonardo B.M., Li, Guanguan, Mian, Md Yeunus, Sharmin, Dishary, Guimarães, Francisco S., Cook, James M., Gomes, Felipe V.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 25.06.2022
• Subjects: Anxiety; Depression; Excitatory-inhibitory balance; GABAA receptors; GL-II-73; Schizophrenia; SH-053–2′F-R-CH3; SH-053–2′F-R-CH3; Schizophrenia; Depression; Excitatory-inhibitory balance; Anxiety; GL-II-73; GABAA receptors

Dysregulation of GABAergic neurotransmission has long been implicated in several psychiatric disorders, including schizophrenia, depression, and anxiety disorders. Alpha 5 subunit-containing GABAA receptors (α5-GABAAR), which are expressed mainly by pyramidal neurons in the hippocampus, have been pr...