Increased Frequencies of Myelin Oligodendrocyte Glycoprotein/MHC Class II-Binding CD4 Cells in Patients with Multiple Sclerosis

• Published in: The Journal of immunology (1950) Vol. 187; no. 2; pp. 1039 - 1046
• Main Authors: Raddassi, Khadir, Kent, Sally C, Yang, Junbao, Bourcier, Kasia, Bradshaw, Elizabeth M, Seyfert-Margolis, Vicki, Nepom, Gerald T, Kwok, William W, Hafler, David A
• Format: Journal Article
• Language: English
• Published: England 15.07.2011
• Subjects: Adult; Aged; Amino Acid Substitution - genetics; Amino Acid Substitution - immunology; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes - immunology; CD4-Positive T-Lymphocytes - metabolism; CD4-Positive T-Lymphocytes - pathology; Cell Communication - genetics; Cell Communication - immunology; Cell Line, Transformed; Cells, Cultured; Epitopes, T-Lymphocyte - biosynthesis; Epitopes, T-Lymphocyte - genetics; Female; Gene Frequency - immunology; HLA-DR Antigens - genetics; HLA-DR Antigens - metabolism; HLA-DRB1 Chains; Humans; Immunophenotyping; Male; Middle Aged; Multiple Sclerosis - genetics; Multiple Sclerosis - immunology; Multiple Sclerosis - pathology; Myelin-Associated Glycoprotein - metabolism; Myelin-Oligodendrocyte Glycoprotein; Peptide Fragments - metabolism; Protein Binding - genetics; Protein Binding - immunology; Protein Multimerization - genetics; Protein Multimerization - immunology

Multiple sclerosis (MS) is an autoimmune disease characterized by infiltration of pathogenic immune cells in the CNS resulting in destruction of the myelin sheath and surrounding axons. We and others have previously measured the frequency of human myelin-reactive T cells in peripheral blood. Using T...