Chiral derivatization coupled with liquid chromatography/mass spectrometry for determining ketone metabolites of hydroxybutyrate enantiomers

• Published in: Chinese chemical letters Vol. 29; no. 1; pp. 115 - 118
• Main Authors: Cheng, Qing-Yun, Xiong, Jun, Wang, Fang, Yuan, Bi-Feng, Feng, Yu-Qi
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 2018
• Subjects: 2-Hydroxybutyric acid; 3-Hydroxybutyric acid; Chiral derivatization; Enantiomer; Mass spectrometry; 2-Hydroxybutyric acid; 3-Hydroxybutyric acid; Mass spectrometry; Enantiomer; Chiral derivatization

Ketone bodies are small lipid-derived molecules and the metabolism of ketone bodies interfaces with various physiological processes. 3-Hydroxybutyric acid （3HB） is the most stable ketone body and can be employed to supply energy source. 2-Hydroxybutyric acid （2HB）, an isomer of 3HB, was demonstrated...