Ring-opening polymerization of L-lactide using N-heterocyclic molecules: mechanistic, kinetics and DFT studies

• Published in: Polymer chemistry Vol. 1; no. 9; pp. 1491 - 1500
• Main Authors: Katiyar, Vimal, Nanavati, Hemant
• Format: Journal Article
• Language: English
• Published: 01.01.2010
• Subjects: Affinity; Correlation; Drugs; Imidazole; Initiators; Mathematical analysis; Polymerization; Reaction kinetics

We report here our investigations of the mechanism and kinetics of N-heterocyclic molecules as initiators for PLA synthesis. This is a step towards employing life saving drugs based on N-heterocyclic functional groups, to generate carrier-drug complexes in situ, via ring opening polymerization (ROP)...