The enteric metabolite, propionic acid, impairs social behavior and increases anxiety in a rodent ASD model: Examining sex differences and the influence of the estrous cycle

• Published in: Pharmacology, biochemistry and behavior Vol. 231; p. 173630
• Main Authors: Benitah, Katie C., Kavaliers, Martin, Ossenkopp, Klaus-Peter
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.10.2023
• Subjects: Anxiety; Estradiol; Estrous cycle; Gut microbiome; Progesterone; Rat; Sex differences; Short-chain fatty acid; Social behavior; Social behavior; Rat; Short-chain fatty acid; Sex differences; Anxiety; Progesterone; Estrous cycle; Gut microbiome; Estradiol

Research suggests that certain gut and dietary factors may worsen behavioral features of autism spectrum disorder (ASD). Treatment with propionic acid (PPA) has been found to create both brain and behavioral responses in rats that are characteristic of ASD in humans. A consistent male bias in human...