Possible altered mineral metabolism in human anencephalic fetuses

Neural tube defects are congenital abnormalities caused by failure of the neural tube to close during embryogenesis. We investigated trace elements (zinc, copper, manganese, cobalt, nickel, molybdenum, cadmium), livers, pancreata, sciatic nerves, diaphragms, and kidneys collected at autopsy from 33...

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Published inNutrition research (New York, N.Y.) Vol. 25; no. 2; pp. 103 - 109
Main Authors Friel, James K., Longerich, Henry, Jackson, Simon E., Pushpananthan, Chitra, Wright, James R.
Format Journal Article
LanguageEnglish
Published Elsevier Inc 2005
Subjects
Cadmium
congenital abnormalities
diaphragm
dietary minerals
fetus
Human fetus
kidneys
liver
mineral metabolism
nerve tissue
Neural tube defects
pancreas
pregnancy
pregnancy complications
spina bifida
Zinc
Cadmium
Human fetus
Neural tube defects
Zinc
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Abstract Neural tube defects are congenital abnormalities caused by failure of the neural tube to close during embryogenesis. We investigated trace elements (zinc, copper, manganese, cobalt, nickel, molybdenum, cadmium), livers, pancreata, sciatic nerves, diaphragms, and kidneys collected at autopsy from 33 anencephalic fetuses and 22 control fetuses. Collections were done on the right side using a titanium scalpel, plastic forceps, and acid-washed materials. Samples were wet ashed and analyzed using inductively coupled plasma mass spectrometry. The gestational age and birth weight (mean ± SD) of anencephalic fetuses were 25.8 ± 8 weeks and 729 ± 879 g, respectively; those of control fetuses, 28 ± 8 weeks and 1340 ± 1216 g, respectively. Liver concentrations (ppm, dry weight, mean ± SEM) of Zn (1075 ± 56 vs 668 ± 75; P = .001) increased in anencephalic fetuses, suggesting defective transport of Zn. Whether this is part of the cause of neural tube defects or a result of the disease is unclear.
AbstractList Neural tube defects are congenital abnormalities caused by failure of the neural tube to close during embryogenesis. We investigated trace elements (zinc, copper, manganese, cobalt, nickel, molybdenum, cadmium), livers, pancreata, sciatic nerves, diaphragms, and kidneys collected at autopsy from 33 anencephalic fetuses and 22 control fetuses. Collections were done on the right side using a titanium scalpel, plastic forceps, and acid-washed materials. Samples were wet ashed and analyzed using inductively coupled plasma mass spectrometry. The gestational age and birth weight (mean ± SD) of anencephalic fetuses were 25.8 ± 8 weeks and 729 ± 879 g, respectively; those of control fetuses, 28 ± 8 weeks and 1340 ± 1216 g, respectively. Liver concentrations (ppm, dry weight, mean ± SEM) of Zn (1075 ± 56 vs 668 ± 75; P = .001) increased in anencephalic fetuses, suggesting defective transport of Zn. Whether this is part of the cause of neural tube defects or a result of the disease is unclear.
Neural tube defects are congenital abnormalities caused by failure of the neural tube to close during embryogenesis. We investigated trace elements (zinc, copper, manganese, cobalt, nickel, molybdenum, cadmium), livers, pancreata, sciatic nerves, diaphragms, and kidneys collected at autopsy from 33 anencephalic fetuses and 22 control fetuses. Collections were done on the right side using a titanium scalpel, plastic forceps, and acid-washed materials. Samples were wet ashed and analyzed using inductively coupled plasma mass spectrometry. The gestational age and birth weight (mean +/- SD) of anencephalic fetuses were 25.8 +/- 8 weeks and 729 +/- 879 g, respectively; those of control fetuses, 28 +/- 8 weeks and 1340 +/- 1216 g, respectively. Liver concentrations (ppm, dry weight, mean +/- SEM) of Zn (1075 +/- 56 vs 668 +/- 75; P = .001) increased in anencephalic fetuses, suggesting defective transport of Zn. Whether this is part of the cause of neural tube defects or a result of the disease is unclear.
Author Friel, James K.
Longerich, Henry
Wright, James R.
Jackson, Simon E.
Pushpananthan, Chitra
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crossref_primary_10_1289_EHP11872
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Snippet Neural tube defects are congenital abnormalities caused by failure of the neural tube to close during embryogenesis. We investigated trace elements (zinc,...
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SubjectTerms Cadmium
congenital abnormalities
diaphragm
dietary minerals
fetus
Human fetus
kidneys
liver
mineral metabolism
nerve tissue
Neural tube defects
pancreas
pregnancy
pregnancy complications
spina bifida
Zinc
Title Possible altered mineral metabolism in human anencephalic fetuses
URI https://dx.doi.org/10.1016/j.nutres.2004.10.007
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