Possible altered mineral metabolism in human anencephalic fetuses
Neural tube defects are congenital abnormalities caused by failure of the neural tube to close during embryogenesis. We investigated trace elements (zinc, copper, manganese, cobalt, nickel, molybdenum, cadmium), livers, pancreata, sciatic nerves, diaphragms, and kidneys collected at autopsy from 33...
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Published in | Nutrition research (New York, N.Y.) Vol. 25; no. 2; pp. 103 - 109 |
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Language | English |
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2005
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Abstract | Neural tube defects are congenital abnormalities caused by failure of the neural tube to close during embryogenesis. We investigated trace elements (zinc, copper, manganese, cobalt, nickel, molybdenum, cadmium), livers, pancreata, sciatic nerves, diaphragms, and kidneys collected at autopsy from 33 anencephalic fetuses and 22 control fetuses. Collections were done on the right side using a titanium scalpel, plastic forceps, and acid-washed materials. Samples were wet ashed and analyzed using inductively coupled plasma mass spectrometry. The gestational age and birth weight (mean ± SD) of anencephalic fetuses were 25.8 ± 8 weeks and 729 ± 879 g, respectively; those of control fetuses, 28 ± 8 weeks and 1340 ± 1216 g, respectively. Liver concentrations (ppm, dry weight, mean ± SEM) of Zn (1075 ± 56 vs 668 ± 75;
P = .001) increased in anencephalic fetuses, suggesting defective transport of Zn. Whether this is part of the cause of neural tube defects or a result of the disease is unclear. |
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AbstractList | Neural tube defects are congenital abnormalities caused by failure of the neural tube to close during embryogenesis. We investigated trace elements (zinc, copper, manganese, cobalt, nickel, molybdenum, cadmium), livers, pancreata, sciatic nerves, diaphragms, and kidneys collected at autopsy from 33 anencephalic fetuses and 22 control fetuses. Collections were done on the right side using a titanium scalpel, plastic forceps, and acid-washed materials. Samples were wet ashed and analyzed using inductively coupled plasma mass spectrometry. The gestational age and birth weight (mean ± SD) of anencephalic fetuses were 25.8 ± 8 weeks and 729 ± 879 g, respectively; those of control fetuses, 28 ± 8 weeks and 1340 ± 1216 g, respectively. Liver concentrations (ppm, dry weight, mean ± SEM) of Zn (1075 ± 56 vs 668 ± 75;
P = .001) increased in anencephalic fetuses, suggesting defective transport of Zn. Whether this is part of the cause of neural tube defects or a result of the disease is unclear. Neural tube defects are congenital abnormalities caused by failure of the neural tube to close during embryogenesis. We investigated trace elements (zinc, copper, manganese, cobalt, nickel, molybdenum, cadmium), livers, pancreata, sciatic nerves, diaphragms, and kidneys collected at autopsy from 33 anencephalic fetuses and 22 control fetuses. Collections were done on the right side using a titanium scalpel, plastic forceps, and acid-washed materials. Samples were wet ashed and analyzed using inductively coupled plasma mass spectrometry. The gestational age and birth weight (mean +/- SD) of anencephalic fetuses were 25.8 +/- 8 weeks and 729 +/- 879 g, respectively; those of control fetuses, 28 +/- 8 weeks and 1340 +/- 1216 g, respectively. Liver concentrations (ppm, dry weight, mean +/- SEM) of Zn (1075 +/- 56 vs 668 +/- 75; P = .001) increased in anencephalic fetuses, suggesting defective transport of Zn. Whether this is part of the cause of neural tube defects or a result of the disease is unclear. |
Author | Friel, James K. Longerich, Henry Wright, James R. Jackson, Simon E. Pushpananthan, Chitra |
Author_xml | – sequence: 1 givenname: James K. surname: Friel fullname: Friel, James K. email: frielj@ms.umanitoba.ca organization: Department of Nutritional Sciences, Faculty of Human Ecology, University of Manitoba, Winnipeg, MB, Canada R3T 2N2 – sequence: 2 givenname: Henry surname: Longerich fullname: Longerich, Henry organization: Department of Earth Sciences, Memorial University of Newfoundland, St John's, NFLD, A1B 3X9 – sequence: 3 givenname: Simon E. surname: Jackson fullname: Jackson, Simon E. organization: Department of Earth and Planetary Sciences, GEMOC National Key Center, Macquarie University, Sydney, NSW 2109, Australia – sequence: 4 givenname: Chitra surname: Pushpananthan fullname: Pushpananthan, Chitra organization: Department of Laboratory Medicine, Janeway Child Health Center, St John's, NL A1B 3X9 – sequence: 5 givenname: James R. surname: Wright fullname: Wright, James R. organization: Department of Pathology, IWK Health Center, Halifax, NS, B3J 3G9 |
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Cites_doi | 10.1002/tera.1420460405 10.1093/ajcn/33.3.542 10.1002/tera.1420360312 10.2174/1389450033491082 10.3181/00379727-123-31578 10.1111/j.0954-6820.1976.tb12823.x 10.1093/ajcn/33.10.2145 10.1203/00006450-197705000-00005 10.1039/an9901500269 10.1093/hmg/9.11.1615 10.1002/tera.1420050307 10.1007/BF01964094 10.1001/archpedi.1979.02130120052011 10.1073/pnas.97.4.1618 10.1212/WNL.34.4.443 10.1023/A:1012994427351 10.1126/science.177.4043.68 10.1177/146642408610600504 10.1002/ajmg.1320550209 10.1002/tera.1420330307 10.1016/0002-9378(85)90624-6 10.1079/BJN19780079 10.1006/dbio.1996.8449 10.1111/j.1471-0528.1982.tb04635.x |
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Snippet | Neural tube defects are congenital abnormalities caused by failure of the neural tube to close during embryogenesis. We investigated trace elements (zinc,... |
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SubjectTerms | Cadmium congenital abnormalities diaphragm dietary minerals fetus Human fetus kidneys liver mineral metabolism nerve tissue Neural tube defects pancreas pregnancy pregnancy complications spina bifida Zinc |
Title | Possible altered mineral metabolism in human anencephalic fetuses |
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