miR‐141‐5p suppresses vascular smooth muscle cell inflammation, proliferation, and migration via inhibiting the HMGB1/NF‐κB pathway

• Published in: Journal of biochemical and molecular toxicology Vol. 35; no. 8; pp. e22828 - n/a
• Main Authors: Li, Yadong, Li, Haide, Chen, Bin, Yang, Fan, Hao, Zhiying
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc 01.08.2021
• Subjects: Animal models; Apoptosis; Arteriosclerosis; Assaying; Atherosclerosis; Bromodeoxyuridine; Cell migration; Cell proliferation; Chromosome 5; Cytokines; Flow cytometry; HMGB1; HMGB1 protein; Immunomodulation; Inflammation; Low density lipoprotein; miRNA; miR‐141‐5p; Modulators; Molecular modelling; mRNA; Muscles; NF‐κB; Pathogenesis; Polymerase chain reaction; Smooth muscle; vascular smooth muscle cells

MicroRNAs (miRNAs) have been identified as significant modulators in the pathogenesis of atherosclerosis (AS). Additionally, the dysregulation of vascular smooth muscle cells (VSMCs) is a crucial biological event during AS. Our study aimed to explore the functional roles and molecular mechanisms of...