Leptin rs2167270 G > A (G19A) polymorphism may decrease the risk of cancer: A case‐control study and meta‐analysis involving 19 989 subjects
Accumulating evidence has suggested that leptin (LEP) is very important for the development of cancer. Recently, a number of case‐control studies about the relationship of the rs2167270 G > A (G19A) variants in the LEP gene with the risk of cancer have yielded inconsistent results. In this study,...
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| Published in | Journal of cellular biochemistry Vol. 120; no. 7; pp. 10998 - 11007 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
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John Wiley and Sons Inc
01.07.2019
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| Abstract | Accumulating evidence has suggested that leptin (LEP) is very important for the development of cancer. Recently, a number of case‐control studies about the relationship of the rs2167270 G > A (G19A) variants in the LEP gene with the risk of cancer have yielded inconsistent results. In this study, we have carried out a case‐control study [1063 esophagogastric junction adenocarcinoma (EGJA) cases and 1677 controls] in a Chinese population. Furthermore, we carried out a pooled‐analysis of 13 studies involving 8059 cancer patients and 11 930 controls to assess whether the
LEP G19A locus was associated with overall cancer susceptibility. Odds ratios (ORs) with the corresponding 95% confidence intervals (CIs) were harnessed to evaluate the potential association. In our case‐control study, we found an association between the carriers of
LEP 19A allele and EGJA risk. In addition, the results of meta‐analysis also suggested significant associations with cancer risk (A vs G: OR = 0.92, 95% CI = 0.88–0.97,
P = 0.001; AA vs GG: OR = 0.83, 95% CI = 0.74–0.93,
P = 0.001, GA/AA vs GG: OR = 0.93, 95% CI = 0.88–0.99,
P = 0.023 and AA vs GG/GA: OR = 0.83, 95% CI = 0.74–0.92,
P < 0.001). Upon conducting a stratified analysis, we found that
LEP 19A allele might decrease the susceptibility of non‐Hodgkin lymphoma (NHL) and colorectal cancer (CRC). In a stratified‐by‐ethnicity analysis, significant associations were also found in Asians, Caucasians, and mixed populations. We can conclude that the
LEP G19A polymorphism constitutes a decreased risk of cancer.
Accumulating evidence has suggested that leptin (LEP) is very important for the development of cancer. Recently, a number of case‐control studies about the relationship of the rs2167270 G > A (G19A) variants in LEP gene with the risk of cancer have yielded inconsistent results. In this meta‐analysis, we can conclude that the LEP G19A polymorphism constitutes a decreased risk of cancer. |
|---|---|
| AbstractList | Accumulating evidence has suggested that leptin (LEP) is very important for the development of cancer. Recently, a number of case‐control studies about the relationship of the rs2167270 G > A (G19A) variants in the
LEP
gene with the risk of cancer have yielded inconsistent results. In this study, we have carried out a case‐control study [1063 esophagogastric junction adenocarcinoma (EGJA) cases and 1677 controls] in a Chinese population. Furthermore, we carried out a pooled‐analysis of 13 studies involving 8059 cancer patients and 11 930 controls to assess whether the
LEP
G19A locus was associated with overall cancer susceptibility. Odds ratios (ORs) with the corresponding 95% confidence intervals (CIs) were harnessed to evaluate the potential association. In our case‐control study, we found an association between the carriers of
LEP
19A allele and EGJA risk. In addition, the results of meta‐analysis also suggested significant associations with cancer risk (A vs G: OR = 0.92, 95% CI = 0.88–0.97,
P
= 0.001; AA vs GG: OR = 0.83, 95% CI = 0.74–0.93,
P
= 0.001, GA/AA vs GG: OR = 0.93, 95% CI = 0.88–0.99,
P
= 0.023 and AA vs GG/GA: OR = 0.83, 95% CI = 0.74–0.92,
P
< 0.001). Upon conducting a stratified analysis, we found that
LEP
19A allele might decrease the susceptibility of non‐Hodgkin lymphoma (NHL) and colorectal cancer (CRC). In a stratified‐by‐ethnicity analysis, significant associations were also found in Asians, Caucasians, and mixed populations. We can conclude that the
LEP
G19A polymorphism constitutes a decreased risk of cancer. Accumulating evidence has suggested that leptin (LEP) is very important for the development of cancer. Recently, a number of case-control studies about the relationship of the rs2167270 G > A (G19A) variants in the LEP gene with the risk of cancer have yielded inconsistent results. In this study, we have carried out a case-control study [1063 esophagogastric junction adenocarcinoma (EGJA) cases and 1677 controls] in a Chinese population. Furthermore, we carried out a pooled-analysis of 13 studies involving 8059 cancer patients and 11 930 controls to assess whether the LEP G19A locus was associated with overall cancer susceptibility. Odds ratios (ORs) with the corresponding 95% confidence intervals (CIs) were harnessed to evaluate the potential association. In our case-control study, we found an association between the carriers of LEP 19A allele and EGJA risk. In addition, the results of meta-analysis also suggested significant associations with cancer risk (A vs G: OR = 0.92, 95% CI = 0.88-0.97, P = 0.001; AA vs GG: OR = 0.83, 95% CI = 0.74-0.93, P = 0.001, GA/AA vs GG: OR = 0.93, 95% CI = 0.88-0.99, P = 0.023 and AA vs GG/GA: OR = 0.83, 95% CI = 0.74-0.92, P < 0.001). Upon conducting a stratified analysis, we found that LEP 19A allele might decrease the susceptibility of non-Hodgkin lymphoma (NHL) and colorectal cancer (CRC). In a stratified-by-ethnicity analysis, significant associations were also found in Asians, Caucasians, and mixed populations. We can conclude that the LEP G19A polymorphism constitutes a decreased risk of cancer.Accumulating evidence has suggested that leptin (LEP) is very important for the development of cancer. Recently, a number of case-control studies about the relationship of the rs2167270 G > A (G19A) variants in the LEP gene with the risk of cancer have yielded inconsistent results. In this study, we have carried out a case-control study [1063 esophagogastric junction adenocarcinoma (EGJA) cases and 1677 controls] in a Chinese population. Furthermore, we carried out a pooled-analysis of 13 studies involving 8059 cancer patients and 11 930 controls to assess whether the LEP G19A locus was associated with overall cancer susceptibility. Odds ratios (ORs) with the corresponding 95% confidence intervals (CIs) were harnessed to evaluate the potential association. In our case-control study, we found an association between the carriers of LEP 19A allele and EGJA risk. In addition, the results of meta-analysis also suggested significant associations with cancer risk (A vs G: OR = 0.92, 95% CI = 0.88-0.97, P = 0.001; AA vs GG: OR = 0.83, 95% CI = 0.74-0.93, P = 0.001, GA/AA vs GG: OR = 0.93, 95% CI = 0.88-0.99, P = 0.023 and AA vs GG/GA: OR = 0.83, 95% CI = 0.74-0.92, P < 0.001). Upon conducting a stratified analysis, we found that LEP 19A allele might decrease the susceptibility of non-Hodgkin lymphoma (NHL) and colorectal cancer (CRC). In a stratified-by-ethnicity analysis, significant associations were also found in Asians, Caucasians, and mixed populations. We can conclude that the LEP G19A polymorphism constitutes a decreased risk of cancer. Accumulating evidence has suggested that leptin (LEP) is very important for the development of cancer. Recently, a number of case‐control studies about the relationship of the rs2167270 G > A (G19A) variants in the LEP gene with the risk of cancer have yielded inconsistent results. In this study, we have carried out a case‐control study [1063 esophagogastric junction adenocarcinoma (EGJA) cases and 1677 controls] in a Chinese population. Furthermore, we carried out a pooled‐analysis of 13 studies involving 8059 cancer patients and 11 930 controls to assess whether the LEP G19A locus was associated with overall cancer susceptibility. Odds ratios (ORs) with the corresponding 95% confidence intervals (CIs) were harnessed to evaluate the potential association. In our case‐control study, we found an association between the carriers of LEP 19A allele and EGJA risk. In addition, the results of meta‐analysis also suggested significant associations with cancer risk (A vs G: OR = 0.92, 95% CI = 0.88–0.97, P = 0.001; AA vs GG: OR = 0.83, 95% CI = 0.74–0.93, P = 0.001, GA/AA vs GG: OR = 0.93, 95% CI = 0.88–0.99, P = 0.023 and AA vs GG/GA: OR = 0.83, 95% CI = 0.74–0.92, P < 0.001). Upon conducting a stratified analysis, we found that LEP 19A allele might decrease the susceptibility of non‐Hodgkin lymphoma (NHL) and colorectal cancer (CRC). In a stratified‐by‐ethnicity analysis, significant associations were also found in Asians, Caucasians, and mixed populations. We can conclude that the LEP G19A polymorphism constitutes a decreased risk of cancer. Accumulating evidence has suggested that leptin (LEP) is very important for the development of cancer. Recently, a number of case‐control studies about the relationship of the rs2167270 G > A (G19A) variants in LEP gene with the risk of cancer have yielded inconsistent results. In this meta‐analysis, we can conclude that the LEP G19A polymorphism constitutes a decreased risk of cancer. Accumulating evidence has suggested that leptin (LEP) is very important for the development of cancer. Recently, a number of case‐control studies about the relationship of the rs2167270 G > A (G19A) variants in the LEP gene with the risk of cancer have yielded inconsistent results. In this study, we have carried out a case‐control study [1063 esophagogastric junction adenocarcinoma (EGJA) cases and 1677 controls] in a Chinese population. Furthermore, we carried out a pooled‐analysis of 13 studies involving 8059 cancer patients and 11 930 controls to assess whether the LEP G19A locus was associated with overall cancer susceptibility. Odds ratios (ORs) with the corresponding 95% confidence intervals (CIs) were harnessed to evaluate the potential association. In our case‐control study, we found an association between the carriers of LEP 19A allele and EGJA risk. In addition, the results of meta‐analysis also suggested significant associations with cancer risk (A vs G: OR = 0.92, 95% CI = 0.88–0.97, P = 0.001; AA vs GG: OR = 0.83, 95% CI = 0.74–0.93, P = 0.001, GA/AA vs GG: OR = 0.93, 95% CI = 0.88–0.99, P = 0.023 and AA vs GG/GA: OR = 0.83, 95% CI = 0.74–0.92, P < 0.001). Upon conducting a stratified analysis, we found that LEP 19A allele might decrease the susceptibility of non‐Hodgkin lymphoma (NHL) and colorectal cancer (CRC). In a stratified‐by‐ethnicity analysis, significant associations were also found in Asians, Caucasians, and mixed populations. We can conclude that the LEP G19A polymorphism constitutes a decreased risk of cancer. |
| Author | Yang, Jing Zhong, Zhihui Chen, Jianping Tang, Weifeng |
| AuthorAffiliation | 3 Department of Cardiothoracic Surgery Affiliated People’s Hospital of Jiangsu University Zhenjiang Jiangsu China 1 Department of Gastroenterology The Third Affiliated Hospital of Soochow University Changzhou Jiangsu China 2 Department of Orthopaedics Fuzhou Second Hospital Affiliated to Xiamen University Fuzhou Fujian China |
| AuthorAffiliation_xml | – name: 1 Department of Gastroenterology The Third Affiliated Hospital of Soochow University Changzhou Jiangsu China – name: 2 Department of Orthopaedics Fuzhou Second Hospital Affiliated to Xiamen University Fuzhou Fujian China – name: 3 Department of Cardiothoracic Surgery Affiliated People’s Hospital of Jiangsu University Zhenjiang Jiangsu China |
| Author_xml | – sequence: 1 givenname: Jing surname: Yang fullname: Yang, Jing organization: The Third Affiliated Hospital of Soochow University – sequence: 2 givenname: Zhihui surname: Zhong fullname: Zhong, Zhihui organization: Fuzhou Second Hospital Affiliated to Xiamen University – sequence: 3 givenname: Weifeng orcidid: 0000-0002-4157-4057 surname: Tang fullname: Tang, Weifeng email: twf001001@126.com organization: Affiliated People’s Hospital of Jiangsu University – sequence: 4 givenname: Jianping surname: Chen fullname: Chen, Jianping email: cjp7668@163.com organization: The Third Affiliated Hospital of Soochow University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30697798$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1002_cam4_7178 crossref_primary_10_2147_PGPM_S258672 crossref_primary_10_1002_jcla_23351 crossref_primary_10_1016_j_clinre_2021_101724 crossref_primary_10_1042_BSR20191729 crossref_primary_10_3390_ijms232415530 crossref_primary_10_1515_hmbci_2022_0020 crossref_primary_10_3389_fonc_2021_754162 crossref_primary_10_1042_BSR20203461 crossref_primary_10_1080_07391102_2021_2020169 |
| Cites_doi | 10.1093/humrep/des147 10.1002/sim.1186 10.3233/CBM-2010-0154 10.3945/an.115.008946 10.1007/s12603-013-0392-1 10.3322/caac.21338 10.18632/oncotarget.22619 10.1038/s41416-018-0106-x 10.1002/ijc.23135 10.18632/oncotarget.20104 10.1158/1055-9965.779.13.5 10.1002/pros.20933 10.1097/MD.0000000000011345 10.1007/s13277-014-2088-5 10.1371/journal.pone.0037846 10.2147/OTT.S153931 10.1007/s10552-009-9427-7 10.1038/sj.bjc.6602762 10.1002/ijc.24043 10.1093/nsr/nwv054 10.1002/jcb.26580 10.1158/1055-9965.EPI-08-0023 10.1136/bmjopen-2017-018859 10.1155/2015/173218 10.5468/ogs.2016.59.4.279 10.1016/0197-2456(86)90046-2 10.1016/j.suronc.2018.03.001 10.1038/sj.ijo.0800770 10.1159/000444484 |
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| Keywords | meta-analysis polymorphism risk leptin |
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| Title | Leptin rs2167270 G > A (G19A) polymorphism may decrease the risk of cancer: A case‐control study and meta‐analysis involving 19 989 subjects |
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