Modular Access to P(V)‐Stereogenic Compounds via Cu‐Catalyzed Desymmetrization of (Thio)Phosphonic Dichlorides

• Published in: Angewandte Chemie International Edition Vol. 64; no. 34; pp. e202509807 - n/a
• Main Authors: Yao, Hong‐Qing, Cai, Yue‐Ming, Xie, Tian, Lv, Ji‐Yuan, Fang, Shuai‐Shuai, Li, Ming‐Hong, Shang, Ming
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 18.08.2025
• Edition: International ed. in English
• Subjects: Acids; Asymmetric copper catalysis; Catalysis; Chiral phosphorus (V) center; Copper; Dichlorides; Functional groups; Functional materials; Lewis acid; Modular engineering; Nucleic acids; Nucleoside analogs; Phosphorus; Scalable synthesis; Stereodivergent synthesis; Stereoselectivity; Asymmetric copper catalysis; Scalable synthesis; Chiral phosphorus (V) center; Stereodivergent synthesis

Chiral phosphorus(V) centers—particularly those bearing fully heteroatom‐substituted frameworks—are key stereochemical motifs in pharmaceuticals, nucleic acid therapeutics, and functional materials. However, their stereoselective construction remains a long‐standing challenge in synthetic chemistry....